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Автор Kovač, Zdenko
Автор Schwartz, Ronald H.
Дата выпуска 1989
dc.description [B10.A(4R) × B10.PL]F<sub>1</sub> mice are low responders to pigeon cytochrome c, while [B10.A(2R) × B10.PL]F<sub>1</sub> and B10.A mice are high responders. The in vivo site at which the different aliomorphs of the E<sub>a</sub> Ia molecule exert their Ir gene effect on the immune response to pigeon cytochrome c was examined by creating two different sets of radiation-induced bone marrow chimeras. [B10.A(4R) × B10.PL]F<sub>1</sub>(b.m.) → B10.A(lrr.) chimeras, which possess antigen-presenting cells (APC) of the low responder, but whose T cells are educated in a high responder environment, were found to be low responders to pigeon cytochromec. In contrast, B10.A(b.m.) → [B10.A(4R) × B10.PL]F<sub>1</sub>(lrr.) chimeras, which possess APC of the high responder type, but whose T cells are educated in a low responder environment, responded to pigeon cytochrome c Addition of B10.A APC to the first type of chimera, both prior to antigen priming and at the time of the secondary challenge in vitro, converted 50% of the animals to responders Furthermore, [B10.A(4R) × B10.PL]F<sub>1</sub> mice responded to pigeon cytochrome c If they were primed with a 10-fold greater antigen dose and restimulated in vitro In the presence of B10.A APC. These results suggest that the primary site of the Ir gene defect in this system is at the level of antigen presentation and not in the T cell repertoire.
Формат application.pdf
Издатель Oxford University Press
Копирайт © Oxford University Press
Тема T cell proliferation
Тема bone marrow chimeras
Тема Articles
Название The nature of the immune response (Ir) gene defect for pigeon cytochrome c in [B10.A(4R) × B10.PL]F<sub>1</sub> mice
Тип research-article
DOI 10.1093/intimm/1.1.1
Electronic ISSN 1460-2377
Print ISSN 0953-8178
Журнал International Immunology
Том 1
Первая страница 1
Последняя страница 10
Аффилиация Kovač Zdenko; Department of Pathophysiology, Medical Faculty of Zagreb, KBC-REBRO, Kišpatičeva
Аффилиация Schwartz Ronald H.; Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Выпуск 1

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