| Автор | čala, Svetlana |
| Автор | Mažuran, Renata |
| Автор | Kordić, Darka |
| Дата выпуска | 1990 |
| dc.description | The evidence indicating the important role of natural killer (NK) cells in immune surveillance against tumours and certain infections is accumulating. Uraemic and dialysed patients are known to be at greater risk of infections and malignant diseases. NK cells were analysed in patients with advanced uraemia, and in patients treated with different dialysis techniques. Number of NK cells was morphologically identified as large granular lymphocytes in blood smears. NK activity was determined as mononuclear cell cytotoxicity against K562 cells. In a group of uraemic patients, large granular lymphocyte number was reduced to 39%, and NK activity to 41%-52% of control values. Large granular lymphocyte number and NK activity in patients haemodialysed on cuprophane membranes was significantly reduced, compared to corresponding values in controls and uraemic patients, declining to 17% and 8%–16% of respective control values. In a group of patients treated by CAPD, and in a group haemodialysed on polyacrylonitrile membranes, NK activity was close to values in the uraemic group, but significantly greater than those of cuprophanehaemodialysed patients. Haemodialysis on cuprophane membranes has an additional negative effect on NK cells, which are already seriously depressed by the uraemic state. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1990 European Dialysis and Transplant Association-European Renal Association |
| Тема | CAPD |
| Тема | Cuprophane membrane |
| Тема | Haemodialysis |
| Тема | Natural killer |
| Тема | Polyacrylonitrile membrane |
| Тема | Uraemia |
| Тема | Original Articles |
| Название | Negative Effect of Uraemia and Cuprophane Haemodialysis on Natural Killer Cells |
| Тип | research-article |
| DOI | 10.1093/ndt/5.6.437 |
| Electronic ISSN | 1460-2385 |
| Print ISSN | 0931-0509 |
| Журнал | Nephrology Dialysis Transplantation |
| Том | 5 |
| Первая страница | 437 |
| Последняя страница | 440 |
| Аффилиация | čala Svetlana; General Hospital J Kajfeš |
| Аффилиация | Mažuran Renata; Institute of Immunology |
| Аффилиация | Kordić Darka; Clinical Hospital M Stojanović |
| Выпуск | 6 |
