| Автор | Bachmann, Martin F. |
| Автор | Zinkernagel, Rolf M. |
| Дата выпуска | 1997 |
| dc.description | ▪ Abstract Neutralizing antiviral B cell responses differ in various aspects from the many usually measured B cell responses specific for protein in adjuvants. In particular, such neutralizing antiviral B cell responses are more rapidly induced, reach higher titers, are longer lived, and are efficiently generated without adjuvants. Evidence is summarized here that the repetitiveness of many viral antigens is a key factor responsible for the efficiency of these B cell responses, amplifying B cells early and rapidly for potent IgM responses and also for efficient switching to IgG. The data reviewed indicate that B cells discriminate antigen patterns via the degree of surface Ig-cross-linking and use antigen repetitiveness as a self/nonself discriminator. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | NEUTRALIZING ANTIVIRAL B CELL RESPONSES |
| DOI | 10.1146/annurev.immunol.15.1.235 |
| Print ISSN | 0732-0582 |
| Журнал | Annual Review of Immunology |
| Том | 15 |
| Первая страница | 235 |
| Последняя страница | 270 |
| Аффилиация | Bachmann, Martin F.; Institute for Experimental Immunology, Department of Pathology, University of Zürich, Schmelzbergstr. 12, Zürich, CH-8091 Switzerland |
