| Автор | Berland, Robert |
| Автор | Wortis, Henry H. |
| Дата выпуска | 2002 |
| dc.description | ▪ Abstract Whether B-1a (CD5+) cells are a distinct lineage derived from committed fetal/neonatal precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown signals remains controversial. Recent evidence indicates that B-1a cells can derive from adult precursors expressing an appropriate specificity when the (self-) antigen is present. Antibody specificity determines whether a B cell expressing immunoglobulin transgenes has a B-2, B-1a or marginal zone (MZ) phenotype. MZ cells share many phenotypic characteristics of B-1 cells and, like them, appear to develop in response to T independent type 2 antigens. Because fetal-derived B cell progenitors fail to express terminal deoxynucleotidyl transferase (TdT) and for other reasons, they are likely to express a repertoire that allows selection into the B-1a population. As it is selected by self-antigen, the B-1 repertoire tends to be autoreactive. This potentially dangerous repertoire is also useful, as B-1 cells are essential for resistance to several pathogens and they play an important role in mucosal immunity. The CD5 molecule can function as a negative regulator of BCR signaling that may help prevent inappropriate activation of autoreactive B-1a cells. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | ORIGINS AND FUNCTIONS OF B-1 CELLS WITH NOTES ON THE ROLE OF CD5 |
| DOI | 10.1146/annurev.immunol.20.100301.064833 |
| Print ISSN | 0732-0582 |
| Журнал | Annual Review of Immunology |
| Том | 20 |
| Первая страница | 253 |
| Последняя страница | 300 |
| Аффилиация | Berland, Robert; Department of Pathology, Tufts University School of Medicine and the Program in Immunology, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111; e-mail: henry.wortis@tufts.edu rberland@opal.tufts.edu |
