| Автор | Underhill, David M. |
| Автор | Ozinsky, Adrian |
| Дата выпуска | 2002 |
| dc.description | ▪ Abstract The phagocytic response of innate immune cells such as macrophages is defined by the activation of complex signaling networks that are stimulated by microbial contact. Many individual proteins have been demonstrated to participate in phagocytosis, and the application of high-throughput tools has indicated that many more remain to be described. In this review, we examine this complexity and describe how during recognition, multiple receptors are simultaneously engaged to mediate internalization, activate microbial killing, and induce the production of inflammatory cytokines and chemokines. Many signaling molecules perform multiple functions during phagocytosis, and these molecules are likely to be key regulators of the process. Indeed, pathogenic microorganisms target many of these molecules in their attempts to evade destruction. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | PHAGOCYTOSIS OF MICROBES: Complexity in Action |
| DOI | 10.1146/annurev.immunol.20.103001.114744 |
| Print ISSN | 0732-0582 |
| Журнал | Annual Review of Immunology |
| Том | 20 |
| Первая страница | 825 |
| Последняя страница | 852 |
| Аффилиация | Underhill, David M.; Institute for Systems Biology, 1441 North 34 Street, Seattle, Washington 98103s; e-mail: dunderhill@systemsbiology.org aozinsky@systemsbiology.org |
