| Автор | Quezada, Sergio A. |
| Автор | Jarvinen, Lamis Z. |
| Автор | Lind, Evan F. |
| Автор | Noelle, Randolph J. |
| Дата выпуска | 2004 |
| dc.description | Development of the acquired immune response is dependent on the signaling of CD40 by its ligand, CD154. These molecules govern both the magnitude and quality of humoral- and cell-mediated immunity. A litany of studies have conclusively documented that blockade of this ligand-receptor pair can prevent, and also intervene in, the progression of antibody- and cell-mediated autoimmune diseases, and can instill long-lived allogeneic and xenogeneic graft tolerance. Many effector mechanisms of inflammation are abolished as a result of CD154 blockade, but we are now beginning to understand that CD154 blockade may, in some instances, engender long-lived, antigen-specific tolerance. In the context of transplantation tolerance, we present a hypothesis that αCD154 blockade is most effective at inducing long-lived allospecific tolerance if anergy and regulation can be elicited prior to the onslaught of inflammation that is induced by grafting (preemptive tolerance). This facet of αCD154-induced tolerance appears to co-opt the normal processes of peripheral tolerance induced by immature DCs and can be exploited to induce long-lived antigen-specific tolerance. The underlying science and the prospects for inducing long-lived antigen-specific tolerance in a model of allograft tolerance through CD154 blockade are presented and discussed. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | CD40/CD154 Interactions at the Interface of Tolerance and Immunity |
| DOI | 10.1146/annurev.immunol.22.012703.104533 |
| Print ISSN | 0732-0582 |
| Журнал | Annual Review of Immunology |
| Том | 22 |
| Первая страница | 307 |
| Последняя страница | 328 |
| Аффилиация | Quezada, Sergio A.; Department of Microbiology and Immunology, Dartmouth Medical School , Lebanon, New Hampshire 03756 ; email: RJN@dartmouth.edu |
