| Автор | Walsh, Matthew C. |
| Автор | Kim, Nacksung |
| Автор | Kadono, Yuho |
| Автор | Rho, Jaerang |
| Автор | Lee, Soo Young |
| Автор | Lorenzo, Joseph |
| Автор | Choi, Yongwon |
| Дата выпуска | 2006 |
| dc.description | Abstract Studies of bone and the immune system have converged in recent years under the banner of osteoimmunology. The immune system is spawned in the bone marrow reservoir, and investigators now recognize that important niches also exist there for memory lymphocytes. At the same time, various factors produced during immune responses are capable of profoundly affecting regulation of bone. Mechanisms have evolved to prevent excessive interference by the immune system with bone homeostasis, yet pathologic bone loss is a common sequela associated with autoimmunity and cancer. There are also developmental links, or parallels, between bone and the immune system. Cells that regulate bone turnover share a common precursor with inflammatory immune cells and may restrict themselves anatomically, in part by utilizing a signaling network analogous to lymphocyte costimulation. Efforts are currently under way to further characterize how these two organ systems overlap and to develop therapeutic strategies that benefit from this understanding. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism |
| DOI | 10.1146/annurev.immunol.24.021605.090646 |
| Print ISSN | 0732-0582 |
| Журнал | Annual Review of Immunology |
| Том | 24 |
| Первая страница | 33 |
| Последняя страница | 63 |
| Аффилиация | Walsh, Matthew C.; Department of Pathology and Laboratory Medicine, AFCRI, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; email: mcw@mail.med.upenn.edu , ykadono-tky@umin.ac.jp , ychoi3@mail.med.upenn.edu |
