Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivity, Cardiovascular Disease, and Drug Metabolism
Costa, Lucio G.; Cole, Toby B.; Jarvik, Gail P.; Furlong, Clement E.; Costa, Lucio G.; Departments of Environmental Health Division of Medical Genetics, University of Washington, Seattle, Washington 98195; e-mail: lgcosta@u.washington.edu
Журнал:
Annual Review of Medicine
Дата:
2003
Аннотация:
This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
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