| Автор | Costa, Lucio G. |
| Автор | Cole, Toby B. |
| Автор | Jarvik, Gail P. |
| Автор | Furlong, Clement E. |
| Дата выпуска | 2003 |
| dc.description | This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivity, Cardiovascular Disease, and Drug Metabolism |
| DOI | 10.1146/annurev.med.54.101601.152421 |
| Print ISSN | 0066-4219 |
| Журнал | Annual Review of Medicine |
| Том | 54 |
| Первая страница | 371 |
| Последняя страница | 392 |
| Аффилиация | Costa, Lucio G.; Departments of Environmental Health Division of Medical Genetics, University of Washington, Seattle, Washington 98195; e-mail: lgcosta@u.washington.edu |
