1,6-Dinitropyrene: Mutagenicity in Salmonella and Carcinogenicity in BALB/c Mice2
Tokiwa, Hiroshi; Otofuji, Takeshi; Horikawa, Kazumi; Kitamori, Shigeji; Otsuka, Hisashi; Manabe, Yoshiki; Kinouchi, Takemi; Ohnishi, Yoshinari; Tokiwa Hiroshi; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center; Otofuji Takeshi; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center; Horikawa Kazumi; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center; Kitamori Shigeji; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center; Otsuka Hisashi; Department of Pathology, School of Medicine, The University of Tokushima; Manabe Yoshiki; Department of Bacteriology, School of Medicine, The University of Tokushima; Kinouchi Takemi; Department of Bacteriology, School of Medicine, The University of Tokushima; Ohnishi Yoshinari; Department of Bacteriology, School of Medicine, The University of Tokushima
Журнал:
JNCI: Journal of the National Cancer Institute
Дата:
1984
Аннотация:
AbstractIn tests on the carcinogenicity of 1,6-dinitropyrene [(1,6-DNP) CAS: 42397-64-8] and 1-nitropyrene [(1-NP) CAS: 5522-43-0], 0.1 mg of each compound was inoculated sc into BALB/c mice once a week for 20 weeks. In the group given injections of 1,6-DNP the first tumor appeared on day 112, and 10 of the 20 mice developed tumors at the injection site by 45 weeks after the first injection. However, no tumors were induced in any of the mice that received injections of 1-NP. All of the induced tumors were transplantable for more than five generations in male BALB/c mice. Most of the tumors showed the characteristic histologic features of malignant fibrous histiocytoma.
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