| Автор | Tokiwa, Hiroshi |
| Автор | Otofuji, Takeshi |
| Автор | Horikawa, Kazumi |
| Автор | Kitamori, Shigeji |
| Автор | Otsuka, Hisashi |
| Автор | Manabe, Yoshiki |
| Автор | Kinouchi, Takemi |
| Автор | Ohnishi, Yoshinari |
| Дата выпуска | 1984 |
| dc.description | AbstractIn tests on the carcinogenicity of 1,6-dinitropyrene [(1,6-DNP) CAS: 42397-64-8] and 1-nitropyrene [(1-NP) CAS: 5522-43-0], 0.1 mg of each compound was inoculated sc into BALB/c mice once a week for 20 weeks. In the group given injections of 1,6-DNP the first tumor appeared on day 112, and 10 of the 20 mice developed tumors at the injection site by 45 weeks after the first injection. However, no tumors were induced in any of the mice that received injections of 1-NP. All of the induced tumors were transplantable for more than five generations in male BALB/c mice. Most of the tumors showed the characteristic histologic features of malignant fibrous histiocytoma. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Тема | Investigations on Nonhuman Systems |
| Название | 1,6-Dinitropyrene: Mutagenicity in Salmonella and Carcinogenicity in BALB/c Mice2 |
| Тип | research-article |
| DOI | 10.1093/jnci/73.6.1359 |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 73 |
| Первая страница | 1359 |
| Последняя страница | 1363 |
| Аффилиация | Tokiwa Hiroshi; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center |
| Аффилиация | Otofuji Takeshi; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center |
| Аффилиация | Horikawa Kazumi; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center |
| Аффилиация | Kitamori Shigeji; Epidemiology and Bacteriology Division, Fukuoka Environmental Research Center |
| Аффилиация | Otsuka Hisashi; Department of Pathology, School of Medicine, The University of Tokushima |
| Аффилиация | Manabe Yoshiki; Department of Bacteriology, School of Medicine, The University of Tokushima |
| Аффилиация | Kinouchi Takemi; Department of Bacteriology, School of Medicine, The University of Tokushima |
| Аффилиация | Ohnishi Yoshinari; Department of Bacteriology, School of Medicine, The University of Tokushima |
| Выпуск | 6 |
