A one-step, enantioselective reduction of ethyl nicotinate to ethyl nipecotinate using a constrained, chiral, heterogeneous catalystElectronic supplementary information (ESI) available: <sup>1</sup>H, <sup>13</sup>C and <sup>31</sup>P NMR spectroscopic data for the ferrocenyl precursor 2, the anchored heterogeneous catalyst and the silsesquioxane-bound homogeneous catalyst. See http://www.rsc.org/suppdata/cc/b0/b005689h/
Raynor, Stuart A.; Thomas, John Meurig; Raja, Robert; Johnson, Brian F. G.; Bell, Robert G.; Mantle, Mike D.; Raynor Stuart A.; Davy-Faraday Research Laboratory, The Royal Institution of Great Britain; Thomas John Meurig; Davy-Faraday Research Laboratory, The Royal Institution of Great Britain; Raja Robert; Davy-Faraday Research Laboratory, The Royal Institution of Great Britain; Johnson Brian F. G.; University of Cambridge, Department of Chemistry; Bell Robert G.; University of Cambridge, Department of Chemistry; Mantle Mike D.; Department of Chemical Engineering, The University of Cambridge
Журнал:
Chemical Communications
Дата:
2000
Аннотация:
A chiral catalyst derived from 1,1â ²-bis(diphenylphosphino)ferrocene and anchored within MCM-41 displays remarkable increases in both enantioselectivity and activity, in the hydrogenation of ethyl nicotinate to ethyl nipecotinate, when compared to an analogous homogeneous model compound.
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