Synthesis of deuterium labelledl- andd-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)—implications for carbapenem biosynthesis
Sorensen, John L.; Sleeman, Mark C.; Schofield, Christopher J.; Sorensen John L.; Chemistry Research Laboratory and Oxford Centre for Molecular Sciences, Department of Chemistry, University of Oxford; Sleeman Mark C.; Chemistry Research Laboratory and Oxford Centre for Molecular Sciences, Department of Chemistry, University of Oxford; Schofield Christopher J.; Chemistry Research Laboratory and Oxford Centre for Molecular Sciences, Department of Chemistry, University of Oxford
Журнал:
Chemical Communications
Дата:
2005
Аннотация:
Carboxymethylproline synthase was shown to condense l-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of d-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA.
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