Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene–tetrahymanol cyclase of Tetrahymena pyriformis
GinerCurrent address: Department of, José-Luis; Rocchetti, Stefano; Neunlist, Serge; Rohmer, Michel; Arigoni, Duilio; GinerCurrent address: Department of Chemistry, State University of New York - ESF, Syracuse, NY 13210, USA. E-mail: jlginer@syr.edu, Fax: 315 470 6856, Tel: 315 470 6895. José-Luis; Laboratorium für Organische Chemie, ETH-Hönggerberg HCI H307; Rocchetti Stefano; Laboratorium für Organische Chemie, ETH-Hönggerberg HCI H307; Neunlist Serge; Ecole National Supérieure de Chimie de Mulhouse; Rohmer Michel; Université Louis Pasteur, Institut Le Bel; Arigoni Duilio; Laboratorium für Organische Chemie, ETH-Hönggerberg HCI H307
Журнал:
Chemical Communications
Дата:
2005
Аннотация:
Incubation of samples of 2,3-dihydrosqualene, specifically labeled with deuterium at either carbon position 7 or 11, with an enzyme extract from Tetrahymena pyriformis, containing a squaleneâ tetrahymanol cyclase, provided specimens of euph-7-enes displaying deuterium patterns consistent with the biosynthetic operation of two consecutive 1,2-hydride shifts.
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