A MALDI-chip integrated system with a monitoring window
Brivio, Monica; Tas, Niels R.; Goedbloed, Martijn H.; Gardeniers, Han J. G. E.; Verboom, Willem; van den Berg, Albert; Reinhoudt, David N.; Brivio Monica; Laboratory of Supramolecular Chemistry and Technology, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente; Tas Niels R.; BIOS Lab-on-a-chip Group, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente; Goedbloed Martijn H.; BIOS Lab-on-a-chip Group, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente; Gardeniers Han J. G. E.; BIOS Lab-on-a-chip Group, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente; Verboom Willem; Laboratory of Supramolecular Chemistry and Technology, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente; van den Berg Albert; BIOS Lab-on-a-chip Group, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente; Reinhoudt David N.; Laboratory of Supramolecular Chemistry and Technology, MESA<sup>+</sup> Institute for Nanotechnology, University of Twente
Журнал:
Lab on a Chip
Дата:
2005
Аннотация:
The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the â monitoring windowâ approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.
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