| Автор | Hawkins, Kenneth R. |
| Автор | Steedman, Mark R. |
| Автор | Baldwin, Richard R. |
| Автор | Fu, Elain |
| Автор | Ghosal, Sandip |
| Автор | Yager, Paul |
| Дата выпуска | 2007 |
| dc.description | We present a method for characterizing the adsorption of solutes in microfluidic devices that is sensitive to both long-lived and transient adsorption and can be applied to a variety of realistic device materials, designs, fabrication methods, and operational parameters. We have characterized the adsorption of two highly adsorbing molecules (FITC-labeled bovine serum albumin (BSA) and rhodamine B) and compared these results to two low adsorbing species of similar molecular weights (FITC-labeled dextran and fluorescein). We have also validated our method by demonstrating that two well-known non-fouling strategies [deposition of the polyethylene oxide (PEO)-like surface coating created by radio-frequency glow discharge plasma deposition (RF-GDPD) of tetraethylene glycol dimethyl ether (tetraglyme, CH3O(CH2CH2O)4CH3), and blocking with unlabeled BSA] eliminate the characteristic BSA adsorption behavior observed otherwise. |
| Формат | application.pdf |
| Издатель | Royal Society of Chemistry |
| Название | A method for characterizing adsorption of flowing solutes to microfluidic device surfaces |
| Тип | research-article |
| DOI | 10.1039/b612894g |
| Electronic ISSN | 1473-0189 |
| Print ISSN | 1473-0197 |
| Журнал | Lab on a Chip |
| Том | 7 |
| Первая страница | 281 |
| Последняя страница | 285 |
| Аффилиация | Hawkins Kenneth R.; Department of Bioengineering, University of Washington |
| Аффилиация | Steedman Mark R.; UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley |
| Аффилиация | Baldwin Richard R.; Department of Bioengineering, University of Washington |
| Аффилиация | Fu Elain; Department of Bioengineering, University of Washington |
| Аффилиация | Ghosal Sandip; Department of Mechanical Engineering, Northwestern University |
| Аффилиация | Yager Paul; Department of Bioengineering, University of Washington |
| Выпуск | 2 |
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