ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionineâ Abbreviations used: L-Se-MetH, L-selenomethionine; L-Se-Met, deprotonated L-selenomethionine; L-MetH, L-methionine; L-Met, deprotonated L-methionine.Electronic supplementary information (ESI) available: isotopic distributions and 2-D [<sup>1</sup>Hâ <sup>15</sup>N] HSQC NMR spectra. See http://www.rsc.org/suppdata/dt/b0/b008611h/
Liu, Qin; Zhang, Junyong; Ke, Xiaokang; Mei, Yuhua; Zhu, Longgen; Guo, Zijian; Liu Qin; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University; Department of Food Sciences and Engineering, Nanjing College of Economics; Zhang Junyong; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University; Ke Xiaokang; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University; Mei Yuhua; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University; Zhu Longgen; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University; Guo Zijian; State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University
Журнал:
Dalton Transactions
Дата:
2001
Аннотация:
The reactions of L-selenomethionine (L-Se-MetH) with cisplatin, cis-[PtCl2(NH3)2], were investigated using electrospray mass spectroscopy (ESMS) and 2-D [<sup>1</sup>Hâ <sup>15</sup>N] NMR spectroscopy. The reaction intermediates and products identified were cis-[PtCl(L-Se-MetH)(NH3)2]<sup>+</sup>, cis-[Pt(L-Se-Met)(NH3)2]<sup>+</sup>, [PtCl(L-Se-MetH)(NH3)]<sup>+</sup> and [Pt(L-Se-Met)(L-Se-MetH)]<sup>+</sup>. Some binuclear adducts were also detected by ESMS during the reaction, although they existed in minor amounts. Similar reactions with L-MetH were also conducted under similar conditions for comparison. This work provides the first detailed studies on the reaction of a platinum-based drug with L-Se-MetH.
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