Investigation of the Lewis acid mediated stereoselective cyclization of cationic aminyl radicals leading to substituted pyrrolidines
Sjöholm, à sa; Hemmerling, Martin; Pradeille, Nicolas; Somfai, Peter; Sjöholm à sa; Organic Chemistry, Department of Chemistry, Royal Institute of Technology; Hemmerling Martin; Organic Chemistry, Department of Chemistry, Royal Institute of Technology; Pradeille Nicolas; Organic Chemistry, Department of Chemistry, Royal Institute of Technology; Somfai Peter; Organic Chemistry, Department of Chemistry, Royal Institute of Technology
Журнал:
Journal of the Chemical Society, Perkin Transactions 1
Дата:
2001
Аннотация:
Stereoselective Lewis acid mediated radical cyclizations of variously substituted N-chloropentenylamines afforded the corresponding pyrrolidines with good to excellent diastereoselectivities and in high yields. Several Lewis acids have been screened in an attempt to find an efficient and stereoselective protocol for the formation of pyrrolidines; no apparent correlation between the different Lewis acids and the selectivities obtained was observed.
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