Induction of nuclear aberrations in mouse alveolar macrophages following exposure to <sup>239</sup>PuO<sub>2</sub>. A dose-response study
A Morgan; S R Moores; H Morris; L G Nicholls; R J Talbot; A Morgan; Environ. & Med. Sci. Div., Harwell Lab., UK; S R Moores; Environ. & Med. Sci. Div., Harwell Lab., UK; H Morris; Environ. & Med. Sci. Div., Harwell Lab., UK; L G Nicholls; Environ. & Med. Sci. Div., Harwell Lab., UK; R J Talbot; Environ. & Med. Sci. Div., Harwell Lab., UK
Журнал:
Journal of Radiological Protection
Дата:
1989-06-01
Аннотация:
Groups of CBA/H mice were exposed to <sup>239</sup>PuO<sub>2</sub> by inhalation to give a range of initial alveolar deposits of 20-1660 Bq. They were killed 34 days later and free lung cells recovered by broncho-alveolar lavage. Differential cell counts were made on recovered cells and, in addition, the incidences of alveolar macrophages (AM) with aberrant nuclei and with mitotic figures were scored. The dose-response relationships for the various types of aberrant AM (micronucleate cells, binucleate cells and cells with both types of aberration) are derived. Information on the <sup>239</sup>Pu labelling index of AM is presented, and on its distribution in normal labelled AM and in labelled AM with aberrant nuclei.
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