Mean first-passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding
M. A. Micheelsen; C. Rischel; J. Ferkinghoff-Borg; R. Guerois; L. Serrano
Журнал:
EPL (Europhysics Letters)
Дата:
2003-02-01
Аннотация:
We have analyzed dynamics on the complex free-energy landscape of protein folding in the FOLD-X model, by calculating for each state of the system the mean first-passage time to the folded state. The resulting kinetic map of the folding process shows that it proceeds in jumps between well-defined, local free-energy minima. Closer analysis of the different local minima allows us to reveal secondary, parallel pathways as well as dead ends.
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