We present and discuss in details a concept for the reduction of ion back-flow in GEM-based cascaded gaseous electron multipliers, by incorporating Micro-Hole & Strip Plate (MHSP) elements operating in reversed-bias mode (R-MHSP). About an order of magnitude reduction in ion back-flow is achieved by diverting back-drifting ions from their original path. A R-MHSP/2GEM/MHSP cascaded multiplier operated at total gain of ∼ 1.5 × 10⁵ yielded ion back-flow fractions of 1.5 × 10^-3 and 4 × 10^-4, at drift fields of 0.5 and 0.1 kV/cm, respectively. A 2R-MHSP/MHSP cascaded multiplier operated at a total gain of ∼ 10⁵, yielded an ion back-flow fraction of 3 × 10^-3. We discuss the concept for trapping back-flowing ions in these cascaded multipliers and the relevance to gaseous photomultiplier and TPC applications; directions for future developments are outlined.