Lung cancer: Intragenic ERBB2 kinase mutations in tumours
Stephens, Philip; Hunter, Chris; Bignell, Graham; Edkins, Sarah; Davies, Helen; Teague, Jon; Stevens, Claire; O'Meara, Sarah; Smith, Raffaella; Parker, Adrian; Barthorpe, Andy; Blow, Matthew; Brackenbury, Lisa; Butler, Adam; Clarke, Oliver; Cole, Jennifer; Dicks, Ed; Dike, Angus; Drozd, Anja; Edwards, Ken; Forbes, Simon; Foster, Rebecca; Gray, Kristian; Greenman, Chris; Halliday, Kelly; Hills, Katy; Kosmidou, Vivienne; Lugg, Richard; Menzies, Andy; Perry, Janet; Petty, Robert; Raine, Keiran; Ratford, Lewis; Shepherd, Rebecca; Small, Alexandra; Stephens, Yvonne; Tofts, Calli; Varian, Jennifer; West, Sofie; Widaa, Sara; Yates, Andrew; Brasseur, Francis; Cooper, Colin S.; Flanagan, Adrienne M.; Knowles, Margaret; Leung, Suet Y.; Louis, David N.; Looijenga, Leendert H. J.; Malkowicz, Bruce; Pierotti, Marco A.; Teh, Bin; Chenevix-Trench, Georgia; Weber, Barbara L.; Yuen, Siu T.; Harris, Grace; Goldstraw, Peter; Nicholson, Andrew G.; Futreal, P. Andrew; Wooster, Richard; Stratton, Michael R.; Stephens, Philip; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Cancer Genome Project and Collaborative Group; Hunter, Chris; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Bignell, Graham; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Edkins, Sarah; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Davies, Helen; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Teague, Jon; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Stevens, Claire; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; O'Meara, Sarah; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Smith, Raffaella; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Parker, Adrian; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Barthorpe, Andy; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Blow, Matthew; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Brackenbury, Lisa; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Butler, Adam; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Clarke, Oliver; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Cole, Jennifer; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Dicks, Ed; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Dike, Angus; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Drozd, Anja; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Edwards, Ken; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Forbes, Simon; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Foster, Rebecca; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Gray, Kristian; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Greenman, Chris; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Halliday, Kelly; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Hills, Katy; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Kosmidou, Vivienne; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Lugg, Richard; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Menzies, Andy; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Perry, Janet; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Petty, Robert; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Raine, Keiran; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Ratford, Lewis; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Shepherd, Rebecca; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Small, Alexandra; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Stephens, Yvonne; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Tofts, Calli; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Varian, Jennifer; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; West, Sofie; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Widaa, Sara; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Yates, Andrew; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Brasseur, Francis; Ludwig Institute for Cancer Research, 1200 Brussels, Belgium; Cooper, Colin S.; Institute of Cancer Research, Sutton SM2 5NG, UK; Flanagan, Adrienne M.; Institute of Orthopaedics, University College London, Stanmore HA7 4LP, UK; Knowles, Margaret; Cancer Research UK Clinical Centre, St James's University Hospital, Leeds LS9 7TF, UK; Leung, Suet Y.; University of Hong Kong Department of Pathology, Queen Mary Hospital, Hong Kong; Louis, David N.; Massachusetts General Hospital East, Molecular Pathology Unit, Charlestown, Massachusetts 02129, USA; Looijenga, Leendert H. J.; Laboratory of Pathology/Experimental Patho-Oncology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands; Malkowicz, Bruce; University of Pennsylvania Division of Urology, Philadelphia, Pennsylvania 19104, USA; Pierotti, Marco A.; Instituto Nazionale Tumori and FIRC Institute of Molecular Oncology, Milan, Italy; Teh, Bin; Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA; Chenevix-Trench, Georgia; Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland 4029, Australia; Weber, Barbara L.; University of Pennsylvania Cancer Centre, Philadelphia, Pennsylvania 19104-6160, USA; Yuen, Siu T.; University of Hong Kong Department of Pathology, Queen Mary Hospital, Hong Kong; Harris, Grace; Royal Brompton Hospital, London SW3 6NP, UK.; Goldstraw, Peter; Royal Brompton Hospital, London SW3 6NP, UK.; Nicholson, Andrew G.; Royal Brompton Hospital, London SW3 6NP, UK.; Futreal, P. Andrew; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Wooster, Richard; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Stratton, Michael R.; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Institute of Cancer Research, Sutton SM2 5NG, UK
Журнал:
Nature
Дата:
2004
Аннотация:
The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations.
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