| Автор | Stephens, Philip |
| Автор | Hunter, Chris |
| Автор | Bignell, Graham |
| Автор | Edkins, Sarah |
| Автор | Davies, Helen |
| Автор | Teague, Jon |
| Автор | Stevens, Claire |
| Автор | O'Meara, Sarah |
| Автор | Smith, Raffaella |
| Автор | Parker, Adrian |
| Автор | Barthorpe, Andy |
| Автор | Blow, Matthew |
| Автор | Brackenbury, Lisa |
| Автор | Butler, Adam |
| Автор | Clarke, Oliver |
| Автор | Cole, Jennifer |
| Автор | Dicks, Ed |
| Автор | Dike, Angus |
| Автор | Drozd, Anja |
| Автор | Edwards, Ken |
| Автор | Forbes, Simon |
| Автор | Foster, Rebecca |
| Автор | Gray, Kristian |
| Автор | Greenman, Chris |
| Автор | Halliday, Kelly |
| Автор | Hills, Katy |
| Автор | Kosmidou, Vivienne |
| Автор | Lugg, Richard |
| Автор | Menzies, Andy |
| Автор | Perry, Janet |
| Автор | Petty, Robert |
| Автор | Raine, Keiran |
| Автор | Ratford, Lewis |
| Автор | Shepherd, Rebecca |
| Автор | Small, Alexandra |
| Автор | Stephens, Yvonne |
| Автор | Tofts, Calli |
| Автор | Varian, Jennifer |
| Автор | West, Sofie |
| Автор | Widaa, Sara |
| Автор | Yates, Andrew |
| Автор | Brasseur, Francis |
| Автор | Cooper, Colin S. |
| Автор | Flanagan, Adrienne M. |
| Автор | Knowles, Margaret |
| Автор | Leung, Suet Y. |
| Автор | Louis, David N. |
| Автор | Looijenga, Leendert H. J. |
| Автор | Malkowicz, Bruce |
| Автор | Pierotti, Marco A. |
| Автор | Teh, Bin |
| Автор | Chenevix-Trench, Georgia |
| Автор | Weber, Barbara L. |
| Автор | Yuen, Siu T. |
| Автор | Harris, Grace |
| Автор | Goldstraw, Peter |
| Автор | Nicholson, Andrew G. |
| Автор | Futreal, P. Andrew |
| Автор | Wooster, Richard |
| Автор | Stratton, Michael R. |
| Дата выпуска | 2004 |
| dc.description | The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations. |
| Формат | application.pdf |
| Издатель | Nature Publishing Group |
| Копирайт | Nature Publishing Group |
| Название | Lung cancer: Intragenic ERBB2 kinase mutations in tumours |
| Тип | BRIEF COMMUNICATIONS |
| DOI | 10.1038/431525b |
| Print ISSN | 0028-0836 |
| Журнал | Nature |
| Том | 431 |
| Первая страница | 525 |
| Последняя страница | 526 |
| Аффилиация | Stephens, Philip; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Cancer Genome Project and Collaborative Group |
| Аффилиация | Hunter, Chris; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Bignell, Graham; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Edkins, Sarah; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Davies, Helen; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Teague, Jon; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Stevens, Claire; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | O'Meara, Sarah; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Smith, Raffaella; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Parker, Adrian; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Barthorpe, Andy; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Blow, Matthew; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Brackenbury, Lisa; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Butler, Adam; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Clarke, Oliver; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Cole, Jennifer; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Dicks, Ed; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Dike, Angus; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Drozd, Anja; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Edwards, Ken; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Forbes, Simon; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Foster, Rebecca; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Gray, Kristian; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Greenman, Chris; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Halliday, Kelly; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Hills, Katy; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Kosmidou, Vivienne; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Lugg, Richard; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Menzies, Andy; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Perry, Janet; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Petty, Robert; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Raine, Keiran; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Ratford, Lewis; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Shepherd, Rebecca; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Small, Alexandra; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Stephens, Yvonne; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Tofts, Calli; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Varian, Jennifer; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | West, Sofie; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Widaa, Sara; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Yates, Andrew; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Brasseur, Francis; Ludwig Institute for Cancer Research, 1200 Brussels, Belgium |
| Аффилиация | Cooper, Colin S.; Institute of Cancer Research, Sutton SM2 5NG, UK |
| Аффилиация | Flanagan, Adrienne M.; Institute of Orthopaedics, University College London, Stanmore HA7 4LP, UK |
| Аффилиация | Knowles, Margaret; Cancer Research UK Clinical Centre, St James's University Hospital, Leeds LS9 7TF, UK |
| Аффилиация | Leung, Suet Y.; University of Hong Kong Department of Pathology, Queen Mary Hospital, Hong Kong |
| Аффилиация | Louis, David N.; Massachusetts General Hospital East, Molecular Pathology Unit, Charlestown, Massachusetts 02129, USA |
| Аффилиация | Looijenga, Leendert H. J.; Laboratory of Pathology/Experimental Patho-Oncology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands |
| Аффилиация | Malkowicz, Bruce; University of Pennsylvania Division of Urology, Philadelphia, Pennsylvania 19104, USA |
| Аффилиация | Pierotti, Marco A.; Instituto Nazionale Tumori and FIRC Institute of Molecular Oncology, Milan, Italy |
| Аффилиация | Teh, Bin; Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA |
| Аффилиация | Chenevix-Trench, Georgia; Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Queensland 4029, Australia |
| Аффилиация | Weber, Barbara L.; University of Pennsylvania Cancer Centre, Philadelphia, Pennsylvania 19104-6160, USA |
| Аффилиация | Yuen, Siu T.; University of Hong Kong Department of Pathology, Queen Mary Hospital, Hong Kong |
| Аффилиация | Harris, Grace; Royal Brompton Hospital, London SW3 6NP, UK. |
| Аффилиация | Goldstraw, Peter; Royal Brompton Hospital, London SW3 6NP, UK. |
| Аффилиация | Nicholson, Andrew G.; Royal Brompton Hospital, London SW3 6NP, UK. |
| Аффилиация | Futreal, P. Andrew; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Wooster, Richard; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK |
| Аффилиация | Stratton, Michael R.; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Institute of Cancer Research, Sutton SM2 5NG, UK |
| Выпуск | 7008 |
