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| Автор | The International Consortium for Blood Pressure Genome-Wide Association Studies |
| Дата выпуска | 2011 |
| dc.description | Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (â ¥140â mmâ Hg systolic blood pressure orâ â ¥90â mmâ Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3â GUCY1B3, NPR3â C5orf23, ADM, FURINâ FES, GOSR2, GNASâ EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. |
| Формат | application.pdf |
| Издатель | Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. |
| Копирайт | Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. |
| Название | Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk |
| Тип | LETTERS TO NATURE |
| DOI | 10.1038/nature10405 |
| Print ISSN | 0028-0836 |
| Журнал | Nature |
| Том | 478 |
| Первая страница | 103 |
| Последняя страница | 109 |
| Аффилиация | Ehret, Georg B.; ; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland.; |
| Аффилиация | Munroe, Patricia B.; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. |
| Аффилиация | Bochud, Murielle; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland. |
| Аффилиация | Johnson, Andrew D.; ; |
| Аффилиация | Chasman, Daniel I.; ; |
| Аффилиация | Smith, Albert V.; Icelandic Heart Association, 201 Kópavogur, Iceland.; University of Iceland, 101 Reykajvik, Iceland. |
| Аффилиация | Tobin, Martin D.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK. |
| Аффилиация | Verwoert, Germaine C.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Hwang, Shih-Jen; ;; Center for Population Studies, National Heart Lung, and Blood Institute, Bethesda, Maryland 20824, USA. |
| Аффилиация | Vollenweider, Peter; Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland. |
| Аффилиация | Oâ Reilly, Paul F.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK. |
| Аффилиация | Amin, Najaf; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Bragg-Gresham, Jennifer L.; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48103, USA. |
| Аффилиация | Teumer, Alexander; Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany. |
| Аффилиация | Glazer, Nicole L.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA. |
| Аффилиация | Launer, Lenore; Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. |
| Аффилиация | Hua Zhao, Jing; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK. |
| Аффилиация | Aulchenko, Yurii; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Heath, Simon; Centre National de Génotypage, Commissariat à Lâ Energie Atomique, Institut de Génomique, 91057 Evry, France. |
| Аффилиация | Sõber, Siim; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia. |
| Аффилиация | Luan, Jianâ an; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK. |
| Аффилиация | Dehghan, Abbas; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Chambers, John C.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK. |
| Аффилиация | Shaw-Hawkins, Sue; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. |
| Аффилиация | Org, Elin; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia. |
| Аффилиация | Aspelund, Thor; Icelandic Heart Association, 201 Kópavogur, Iceland.; University of Iceland, 101 Reykajvik, Iceland. |
| Аффилиация | Garcia, Melissa; Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. |
| Аффилиация | Bis, Joshua C.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA. |
| Аффилиация | Lee, Nanette R.; Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City 6000, Philippines. |
| Аффилиация | Peltonen, Leena; ;;; |
| Аффилиация | Burton, Paul R.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK. |
| Аффилиация | Soler Artigas, Maria; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK. |
| Аффилиация | Smith, Nicholas L.; ; |
| Аффилиация | Veldre, Gudrun; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia.; Department of Cardiology, University of Tartu, L. Puusepa 8, 51014 Tartu, Estonia. |
| Аффилиация | Viigimaa, Margus; Tallinn University of Technology, Institute of Biomedical Engineering, Ehitajate tee 5, 19086 Tallinn, Estonia.; Centre of Cardiology, North Estonia Medical Centre, Sütiste tee 19, 13419 Tallinn, Estonia. |
| Аффилиация | Forrester, Terrence; Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica. |
| Аффилиация | McKenzie, Colin A.; Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica. |
| Аффилиация | Salako, Tunde; University of Ibadan, 200284 Ibadan, Nigeria. |
| Аффилиация | Eyheramendy, Susana; Department of Statistics, Pontificia Universidad Catolica de Chile, Vicuña Mackena 4860, Santiago, Chile. |
| Аффилиация | Wichmann, H.-Erich; ; |
| Аффилиация | Zhang, Weihua; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK. |
| Аффилиация | Oâ Donnell, Christopher J.; ; |
| Аффилиация | Arfan Ikram, M.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Shrine, Nick R.G.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK. |
| Аффилиация | Wain, Louise V.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK. |
| Аффилиация | Hofman, Albert; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Mattace-Raso, Francesco U. S.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Demirkan, Ayse; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Isaacs, Aaron; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Rivadeneira, Fernando; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Ala-Korpela, Mika; ; |
| Аффилиация | Tukiainen, Taru; ; |
| Аффилиация | Würtz, Peter; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; |
| Аффилиация | Twee-Hee Ong, Rick; ; |
| Аффилиация | Völker, Uwe; Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany. |
| Аффилиация | Lathrop, Mark; Centre National de Génotypage, Commissariat à Lâ Energie Atomique, Institut de Génomique, 91057 Evry, France. |
| Аффилиация | Zelenika, Diana; Centre National de Génotypage, Commissariat à Lâ Energie Atomique, Institut de Génomique, 91057 Evry, France. |
| Аффилиация | Terzic, Janos; Faculty of Medicine, University of Split, 21000 Split, Croatia. |
| Аффилиация | Zukowska-Szczechowska, Ewa; Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, 41-800, Zabrze, Poland. |
| Аффилиация | Polasek, Ozren; Department of Medical Statistics, Epidemiology and Medical Informatics, Andrija Stampar School of Public Health, University of Zagreb, 10000 Zagreb, Croatia. |
| Аффилиация | Laan, Maris; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia. |
| Аффилиация | Shyong Tai, E; ; |
| Аффилиация | Harris, Tamara B.; Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. |
| Аффилиация | Ridker, Paul M; ; |
| Аффилиация | Tuomilehto, Jaakko; ;; |
| Аффилиация | Sijbrands, Eric J. G.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Loos, Ruth J. F.; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK. |
| Аффилиация | Uitterlinden, Andre G.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Wareham, Nicholas J.; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK. |
| Аффилиация | Gudnason, Vilmundur; Icelandic Heart Association, 201 Kópavogur, Iceland.; University of Iceland, 101 Reykajvik, Iceland. |
| Аффилиация | Witteman, Jacqueline C. M.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands. |
| Аффилиация | Järvelin, Marjo-Riitta; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.;;; |
| Аффилиация | Psaty, Bruce M.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA.; |
| Аффилиация | Abecasis, Gonçalo R.; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48103, USA. |
| Аффилиация | Elliott, Paul; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; |
| Аффилиация | van Duijn, Cornelia M.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Centre of Medical Systems Biology (CMSB 1-2), NGI Erasmus Medical Center, Rotterdam, The Netherlands. |
| Аффилиация | Newton-Cheh, Christopher; ; |
| Аффилиация | Levy, Daniel; ;; Center for Population Studies, National Heart Lung, and Blood Institute, Bethesda, Maryland 20824, USA. |
| Аффилиация | Caulfield, Mark J.; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. |
| Аффилиация | Johnson, Toby; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. |
| Выпуск | 7367 |
