1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine
Norman, Anthony W.; Myrtle, James F.; Miogett, Ronald J.; Nowicki, Henry G.; Williams, Vincent; Popjaák, G.; Department of Biochemistry, University of California, Riverside 92502; Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024
Журнал:
Science
Дата:
1971
Аннотация:
The major polar metabolite of cholecalciferol (vitamin D<sub>3</sub>) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C<sub>27</sub>H<sub>44</sub>0<sub>3</sub> and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine.
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