| Автор | Norman, Anthony W. |
| Автор | Myrtle, James F. |
| Автор | Miogett, Ronald J. |
| Автор | Nowicki, Henry G. |
| Автор | Williams, Vincent |
| Автор | Popjaák, G. |
| Дата выпуска | 1971 |
| dc.description | The major polar metabolite of cholecalciferol (vitamin D<sub>3</sub>) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C<sub>27</sub>H<sub>44</sub>0<sub>3</sub> and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Название | 1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine |
| Тип | research-article |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 173 |
| Первая страница | 51 |
| Последняя страница | 54 |
| Аффилиация | Department of Biochemistry, University of California, Riverside 92502 |
| Аффилиация | Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024 |
| Выпуск | 3991 |
| Библиографическая ссылка | BLUNT, J.W., 25-HYDROXYCHOLECALCIFEROL . A BIOLOGICALLY ACTIVE METABOLITE OF VITAMIN D3, BIOCHEMISTRY 7: 3317 (1968). |
| Библиографическая ссылка | COUSINS, R.J., METABOLISM AND SUBCELLULAR LOCATION OF 25-HYDROXYCHOLECALCIFEROL IN INTESTINAL MUCOSA, BIOCHEMISTRY 9: 1453 (1970). |
| Библиографическая ссылка | FRASER, D.R., UNIQUE BIOSYNTHESIS BY KIDNEY OF A BIOLOGICALLY ACTIVE VITAMIN-D METABOLITE, NATURE 228: 764 (1970). |
| Библиографическая ссылка | HAUSSLER, M.R., ASSOCIATION OF A METABOLITE OF VITAMIN D3 WITH INTESTINAL MUCOSA CHROMATIN IN VIVO, JOURNAL OF BIOLOGICAL CHEMISTRY 243: 4055 (1968). |
| Библиографическая ссылка | HAUSSLER, M.R., CHROMOSOMAL RECEPTOR FOR A VITAMIN D METABOLITE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 62: 155 (1969). |
| Библиографическая ссылка | HAUSSLER, M.R., RAPIDLY ACTING METABOLITE OF VITAMIN-D3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 177 (1971). |
| Библиографическая ссылка | HOLICK, M.F., IDENTIFICATION OF 1,25-DIHYDROXYCHOLECALCIFEROL, A FORM OF VITAMIN-D3 METABOLICALLY ACTIVE IN INTESTINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 803 (1971). |
| Библиографическая ссылка | HORSTING, M, IN VITRO PRODUCTION OF 25-HYDROXYCHOLECALCIFEROL, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 36: 251 (1969). |
| Библиографическая ссылка | LAWSON, DEM, METABOLISM OF VITAMIN D - A NEW CHOLECALCIFEROL METABOLITE, INVOLVING LOSS OF HYDROGEN AT C-1, IN CHICK INTESTINAL NUCLEI, BIOCHEMICAL JOURNAL 115: 269 (1969). |
| Библиографическая ссылка | LAWSON, DEM, IDENTIFICATION OF 1,25-DIHYDROXYCHOLECALCIFEROL, A NEW KIDNEY HORMONE CONTROLLING CALCIUM METABOLISM, NATURE 230: 228 (1971). |
| Библиографическая ссылка | MYRTLE, J.F., IN PRESS. |
| Библиографическая ссылка | MYRTLE, J, EVIDENCE FOR BIOLOGICALLY ACTIVE FORM OF CHOLECALCIFEROL IN INTESTINE, JOURNAL OF BIOLOGICAL CHEMISTRY 245: 1190 (1970). |
| Библиографическая ссылка | MYRTLE, J.F., VITAMIN-D - CHOLECALCIFEROL METABOLITE HIGHLY ACTIVE IN PROMOTING INTESTINAL CALCIUM TRANSPORT, SCIENCE 171: 79 (1971). |
| Библиографическая ссылка | MYRTLE, J.F., THESIS U CALIFORNIA (1971). |
| Библиографическая ссылка | NORMAN, A.W., BASIC STUDIES ON MECHANISM OF ACTION OF VITAMIN D, AMERICAN JOURNAL OF CLINICAL NUTRITION 22: 396 (1969). |
| Библиографическая ссылка | NORMAN, A.W., STUDIES ON CALCIFEROL METABOLISM .1. PRODUCTION OF VITAMIN-D METABOLITE-4B FROM 25-OH-CHOLECALCIFEROL BY KIDNEY HOMOGENATES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42: 1082 (1971). |
| Библиографическая ссылка | NORMAN, A.W., MODE OF ACTION OF VITAMIN D, BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY 43: 97 (1968). |
| Библиографическая ссылка | NORMAN, A.W., IN PRESS. |
