1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture
Raisz, L. G.; Trummel, C. L.; Holick, M. F.; Deluca, H. F.; Departments of Pharmacology and Toxicology and Dentistry and Dental Research, University of Rochester, Rochester, New York 14642; Department of Biochemistry, University of Wisconsin, Madison 53706
Журнал:
Science
Дата:
1972
Аннотация:
1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated <sup>45</sup>45Ca from fetal rat bones in organ culture, at concentrations of 10<sup>-10</sup> to 10<sup>-8</sup>M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.
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