| Автор | Raisz, L. G. |
| Автор | Trummel, C. L. |
| Автор | Holick, M. F. |
| Автор | Deluca, H. F. |
| Дата выпуска | 1972 |
| dc.description | 1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated <sup>45</sup>45Ca from fetal rat bones in organ culture, at concentrations of 10<sup>-10</sup> to 10<sup>-8</sup>M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Копирайт | © 1972 by the American Association for the Advancement of Science |
| Тема | REPORTS |
| Название | 1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture |
| Тип | research-article |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 175 |
| Первая страница | 768 |
| Последняя страница | 769 |
| Аффилиация | Departments of Pharmacology and Toxicology and Dentistry and Dental Research, University of Rochester, Rochester, New York 14642 |
| Аффилиация | Department of Biochemistry, University of Wisconsin, Madison 53706 |
| Выпуск | 4023 |
| Библиографическая ссылка | BLUNT, J.W., SYNTHESIS OF 25-HYDROXYCHOLECALCIFEROL . A BIOLOGICALLY ACTIVE METABOLITE OF VITAMIN D3, BIOCHEMISTRY 8: 671 (1969). |
| Библиографическая ссылка | COUSINS, R.J., METABOLISM AND SUBCELLULAR LOCATION OF 25-HYDROXYCHOLECALCIFEROL IN INTESTINAL MUCOSA, BIOCHEMISTRY 9: 1453 (1970). |
| Библиографическая ссылка | DELUCA, H.F., FAT SOLUBLE VITAMINS 3 (1970). |
| Библиографическая ссылка | FRASER, D.R., UNIQUE BIOSYNTHESIS BY KIDNEY OF A BIOLOGICALLY ACTIVE VITAMIN-D METABOLITE, NATURE 228: 764 (1970). |
| Библиографическая ссылка | GRAY, R, VITAMIN-D METABOLISM - ROLE OF KIDNEY TISSUE, SCIENCE 172: 1232 (1971). |
| Библиографическая ссылка | HAUSLER, M.R., J BIOL CHEM 243: 405 (1968). |
| Библиографическая ссылка | HAUSSLER, M.R., RAPIDLY ACTING METABOLITE OF VITAMIN-D3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 177 (1971). |
| Библиографическая ссылка | HOLICK, M.F., IN PRESS. |
| Библиографическая ссылка | HOLICK, M.F., IDENTIFICATION OF 1,25-DIHYDROXYCHOLECALCIFEROL, A FORM OF VITAMIN-D3 METABOLICALLY ACTIVE IN INTESTINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 803 (1971). |
| Библиографическая ссылка | LAWSON, D.E., BIOCHEM J 150: 269 (1969). |
| Библиографическая ссылка | MCARTHUR, J.W., A FLEXIBLE COMPUTER PROGRAM FOR COMPOSITE ANALYSIS OF SYMMETRICAL AND ASYMMETRICAL BIOLOGIC ASSAYS OF PARALLEL-LINE TYPE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 153: 573 (1966). |
| Библиографическая ссылка | OLSON, E.B., 25-HYDROXYCHOLECALCIFEROL - DIRECT EFFECT ON CALCIUM TRANSPORT, SCIENCE 165: 405 (1969). |
| Библиографическая ссылка | OMDAHL, J, IN PRESS. |
| Библиографическая ссылка | RAISZ, L.G., CELLULAR MECHANISMS (1971). |
| Библиографическая ссылка | RAISZ, L.G., ENDOCRINOLOGY 85: 446 (1969). |
| Библиографическая ссылка | RAISZ, L.G., FAT SOLUBLE VITAMINS 93 (1970). |
| Библиографическая ссылка | RAISZ, L.G., IN PRESS. |
| Библиографическая ссылка | TANAKA, Y, IN PRESS. |
| Библиографическая ссылка | TRUMMEL, C.L., 25-HYDROXYCHOLECALCIFEROL - STIMULATION OF BONE RESORPTION IN TISSUE CULTURE, SCIENCE 163: 1450 (1969). |
| Библиографическая ссылка | TRUMMEL, C.L., UNPUBLISHED OBSERVAT. |
