| Автор | Chimona, T S |
| Автор | Panayiotides, J G |
| Автор | Papadakis, C E |
| Автор | Helidonis, E S |
| Автор | Velegrakis, G A |
| Дата выпуска | 2007 |
| dc.description | Objectives: Assessment of the histopathologic effect of transtympanic and intramuscular administration of dexamethasone in an in vivo experimental animal model of middle-ear mucosal inflammation.Methods: Fifty healthy rabbits weighting 1500–1800 g were randomly divided in three groups. In 10 animals (control group), 0.5 ml of a 20 mg/ml histamine solution was injected transtympanically. In 20 rabbits (group A), histamine challenge followed a three day intramuscular pretreatment with dexamethasone at 1 mg/kg per day. In 20 rabbits (group B), histamine challenge followed pretreatment with dexamethasone via a transtympanic route (0.3 ml, 1.2 mg dexamethasone). Middle-ear mucosa was obtained for histopathology 30 minutes after histamine administration. The following parameters were assessed: inflammation, acute inflammatory component, presence of eosinophils, inflammatory activity and fibrosis.Results: Oedema, vascular dilatation and congestion, inflammation, the presence of an acute (polymorphonuclear) inflammatory component, the presence of eosinophils, and inflammatory activity were found to be of a lesser grade in the mucosae of group B. All differences were found to be statistically highly significant (p<0.01) using the Mann–Whitney test.Conclusion: Our findings validate the transtympanic route of dexamethasone administration in counteracting histamine effects. |
| Издатель | Cambridge University Press |
| Тема | Middle Ear |
| Тема | Mucous Membrane |
| Тема | Inflammation |
| Тема | Steroids |
| Тема | Animal Model |
| Название | Transtympanic versus intramuscular steroid administration in a histamine-induced inflammatory middle-ear modelPresented in part at the Fifth European Congress of Oto-Rhino-Laryngology Head and Neck Surgery, 11–16 September 2004, Rhodes, Greece, and at the XVIII International Federation of Oto-Rhino-Laryngological Societies World Congress, 25–30 June 2005, Rome, Italy. |
| DOI | 10.1017/S0022215106004968 |
| Electronic ISSN | 1748-5460 |
| Print ISSN | 0022-2151 |
| Журнал | The Journal of Laryngology & Otology |
| Том | 121 |
| Первая страница | 630 |
| Последняя страница | 634 |
| Аффилиация | Chimona T S; University of Crete School of Medicine; |
| Аффилиация | Panayiotides J G; University of Athens Medical School (Attikon Hospital) |
| Аффилиация | Papadakis C E; University of Crete School of Medicine |
| Аффилиация | Helidonis E S; University of Crete School of Medicine |
| Аффилиация | Velegrakis G A; University of Crete School of Medicine |
| Выпуск | 7 |
