Antibodies to the axolemma-enriched fraction in the cerebrospinal fluid and serum of patients with multiple sclerosis and other neurological diseases
Rawes, JA; Calabrese, VP; Khan, OA; DeVries, GH; Rawes, JA, Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Richmond, Virginia 23298-0614 USA; Calabrese, VP, Department of Neurology, Medical College of Virginia, Richmond, Virginia 23298-0599 USA; Khan, OA, Department of Neurology, University of Maryland, Baltimore, Maryland 21201-1595 USA; DeVries, GH, Research Service 151, Edward Hines Jr. VA Hospital, 5th and Roosevelt Road, Hines, Illinois 60141 USA
Журнал:
Multiple Sclerosis
Дата:
1997
Аннотация:
Antibodies to an axolemma-enriched fraction (AEF) antigen have been detected in the cerebrospinal fluid (CSF) and serum of patients with Multiple Sclerosis (MS) using an enzyme-linked immunosorbent assay (ELISA). A marginal elevation (P < 0.08) of anti-AEF lgG was found in MS CSF when compared with OND samples. When CSF was diluted to a standardized lgG concentration, the anti-AEF lgG level in MS CSF was significantly elevated (P=0.007) when compared to OND CSF. MS serum was also found to contain a significantly higher level (P < 0.00 I ) of anti-AEF lgG when compared to OND serum using the ELISA technique.
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