A Quantitative Trait Locus Associated with Cognitive Ability in Children
Chorney, M.J.; Chorney, K.; Seese, N.; Owen, M.J.; Daniels, J.; McGuffin, P.; Thompson, L.A.; Detterman, D.K.; Benbow, C.; Lubinski, D.; Eley, T.; Plomin, R.; Chorney, M.J., 1 Department of Microbiology and Immunology, Milton S. Hershey Medical Center, Pennsylvania State University; Chorney, K., 1 Department of Microbiology and Immunology, Milton S. Hershey Medical Center, Pennsylvania State University; Seese, N., 1 Department of Microbiology and Immunology, Milton S. Hershey Medical Center, Pennsylvania State University; Owen, M.J., 2 Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, United Kingdom; Daniels, J., 2 Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, United Kingdom; McGuffin, P., 2 Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, United Kingdom; Thompson, L.A., 3 Department of Psychology, Case Western Reserve University; Detterman, D.K., 3 Department of Psychology, Case Western Reserve University; Benbow, C., 4 Department of Psychology, Iowa State University; Lubinski, D., 4 Department of Psychology, Iowa State University; Eley, T., 5 Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom; Plomin, R., 5 Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
Журнал:
Psychological Science
Дата:
1998
Аннотация:
Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156; average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).
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