The synchrotron radiation from relativistic charged particles gyrating along a static magnetic field is affected by the background medium. We have shown the effect of uniform magnetoplasma, the plasma inhomogeneity and the drifting plasma on the synchrotron radiation. The radiated synchrotron power for frequencies f/f _c ≤ 1 is found to decrease due to the presence of drifting plasma and the synchrotron power in the same frequency range is found to increase due to the presence of plasma in homogeneity. For frequencies f/f _c ≥ 1 the plasma inhomogeneity and drifting plasma show negligible effect.