| Автор | Kirby, Mark L. |
| Автор | Beatty, Stephen |
| Автор | Stack, Jim |
| Автор | Harrison, Michael |
| Автор | Greene, Isabelle |
| Автор | McBrinn, Sean |
| Автор | Carroll, Paula |
| Автор | Nolan, John M. |
| Дата выпуска | 2011 |
| dc.description | The objective of the present study was to investigate whether weight loss is associated with changes in serum concentrations of lutein (L) and zeaxanthin (Z), and/or macular pigment optical density (MPOD). We recruited 104 overweight subjects into this randomised controlled weight loss study. For the intervention group (I group), weight was assessed weekly and body composition, including BMI (kg/m<sup>2</sup>) and body fat (kg and percentage), was assessed at baseline, 6 and 12 months. Weight loss was encouraged using dietary and exercise programmes. MPOD was measured by heterochromatic flicker photometry and serum concentrations of L and Z by HPLC (at baseline, 1, 3, 6 and 12 months). The control (C) group was assessed at baseline and 12 months. Repeated-measures ANOVA (RMA) demonstrated significant weight loss in the I group over the study period (P = 0·000). There was no significant weight change in the C group (P = 0·993). RMA of dietary L and Z, serum L and Z, and MPOD demonstrated no significant time or time × group interaction effect in any of these parameters (P>0·05 for all), with the exception of a significant decrease in the dietary intake of Z seen in both groups, over the study period (P < 0·05). There was a positive and significant relationship between body fat loss (kg) and increase in serum concentrations of L in the I group (r 0·521; P = 0·006). Our finding that a reduction in body composition (e.g. fat mass) is related to increases in serum concentrations of L is consistent with the hypothesis that body fat acts as a reservoir for this carotenoid, and that weight loss can positively influence circulating carotenoid levels. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2010 |
| Тема | Weight loss |
| Тема | Obesity |
| Тема | Serum concentrations of lutein/zeaxanthin |
| Тема | Macular pigment |
| Тема | Human and Clinical Nutrition |
| Название | Changes in macular pigment optical density and serum concentrations of lutein and zeaxanthin in response to weight loss |
| Тип | research-article |
| DOI | 10.1017/S0007114510004721 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 105 |
| Первая страница | 1036 |
| Последняя страница | 1046 |
| Аффилиация | Kirby Mark L.; Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology |
| Аффилиация | Beatty Stephen; Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology |
| Аффилиация | Stack Jim; Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology |
| Аффилиация | Harrison Michael; Sport and Exercise Science, Waterford Institute of Technology |
| Аффилиация | Greene Isabelle; Waterford Regional Hospital |
| Аффилиация | McBrinn Sean; Student Medical Centre, Waterford Institute of Technology |
| Аффилиация | Carroll Paula; Sport and Exercise Science, Waterford Institute of Technology |
| Аффилиация | Nolan John M.; Macular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology |
| Выпуск | 7 |
