| Автор | Diness, Birgitte R. |
| Автор | Martins, Cesário L. |
| Автор | Balé, Carlitos |
| Автор | Garly, May-Lill |
| Автор | Ravn, Henrik |
| Автор | Rodrigues, Amabelia |
| Автор | Whittle, Hilton |
| Автор | Aaby, Peter |
| Автор | Benn, Christine S. |
| Дата выпуска | 2011 |
| dc.description | Vitamin A treatment reduces mortality during acute measles infection, and vitamin A supplementation (VAS) to children above 6 months of age may reduce the incidence of measles infection. The effect of VAS at birth on measles incidence is unknown. In a randomised placebo-controlled trial in Guinea-Bissau, normal-birth-weight newborns were randomised to 50 000 IU (15 mg) VAS or placebo. During the trial, a measles epidemic occurred. We linked data from the trial with data from the measles infection surveillance and studied the effect of VAS on the measles incidence before 12 months of age in both sexes. A total of 165 measles cases were identified among the 4183 children followed from 28 d of age. Up to 6 months of age, the incidence rate ratio of measles for VAS compared with placebo was 0·54 (95 % CI 0·25, 1·15) among boys and 1·57 (95 % CI 0·80, 3·08) among girls (test of interaction, P = 0·04). The corresponding figures at 12 months were 0·67 (95 % CI 0·43, 1·05) and 1·17 (95 % CI 0·76, 1·79) (test of interaction, P = 0·08). VAS compared with placebo tended to be associated with less measles hospitalisation or death during the first 6 months of life in boys (P = 0·06), but not in girls. VAS at birth may affect the susceptibility to measles infection during the first 6 months of life in a sex-differential manner. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2011 |
| Тема | Vitamin A |
| Тема | Sex differences |
| Тема | Measles |
| Тема | Infant mortality |
| Тема | Human and Clinical Nutrition |
| Название | The effect of high-dose vitamin A supplementation at birth on measles incidence during the first 12 months of life in boys and girls: an unplanned study within a randomised trial |
| Тип | research-article |
| DOI | 10.1017/S0007114510005532 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 105 |
| Первая страница | 1819 |
| Последняя страница | 1822 |
| Аффилиация | Diness Birgitte R.; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Martins Cesário L.; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Balé Carlitos; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Garly May-Lill; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Ravn Henrik; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Rodrigues Amabelia; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Whittle Hilton; Medical Research Council |
| Аффилиация | Aaby Peter; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Аффилиация | Benn Christine S.; Bandim Health Project, INDEPTH Network; Bandim Health Project, Statens Serum Institute |
| Выпуск | 12 |
