| Автор | Campeotto, Florence |
| Автор | Suau, Antonia |
| Автор | Kapel, Nathalie |
| Автор | Magne, Fabien |
| Автор | Viallon, Vivian |
| Автор | Ferraris, Laurent |
| Автор | Waligora-Dupriet, Anne-Judith |
| Автор | Soulaines, Pascale |
| Автор | Leroux, Bernard |
| Автор | Kalach, Nicolas |
| Автор | Dupont, Christophe |
| Автор | Butel, Marie-José |
| Дата выпуска | 2011 |
| dc.description | Intestinal bacterial colonisation in pre-term infants is delayed compared with full-term infants, leading to an increased risk of gastrointestinal disease. Modulation of colonisation through dietary supplementation with probiotics or prebiotics could decrease such a risk. The present study evaluated clinical tolerance, the effects on gut microbiota, and inflammatory and immunological mucosal responses to an infant formula adapted for pre-term infants that included in its manufacturing process a fermentation step with two probiotic strains, Bifidobacterium breve C50 and Streptococcus thermophilus 065, inactivated by heat at the end of the process. A total of fifty-eight infants (gestational age: 30–35 weeks), fed either the fermented pre-term formula or a standard pre-term formula, were followed up during their hospital stay. Clinical tolerance, faecal microbiota using a culture and a culture-independent method (temporal temperature gel electrophoresis), faecal calprotectin and secretory IgA were analysed weekly. No difference was observed regarding anthropometric data and digestive tolerance, except for abdominal distension, the incidence of which was lower in infants fed the fermented formula for 2 weeks. Bacterial colonisation was not modified by the type of feeding, particularly for bifidobacteria. Faecal calprotectin was significantly lower in infants fed the fermented formula for 2 weeks, and secretory IgA increased with both mother's milk and the fermented formula. The fermented formula was well tolerated and did not significantly modulate the bacterial colonisation but had benefits on inflammatory and immune markers, which might be related to some features of gastrointestinal tolerance. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2011 |
| Тема | Pre-term infants |
| Тема | Fermented formula |
| Тема | Gut microbiota |
| Тема | Calprotectin |
| Тема | Secretory IgA |
| Тема | Human and Clinical Nutrition |
| Название | A fermented formula in pre-term infants: clinical tolerance, gut microbiota, down-regulation of faecal calprotectin and up-regulation of faecal secretory IgA |
| Тип | research-article |
| DOI | 10.1017/S0007114510005702 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 105 |
| Первая страница | 1843 |
| Последняя страница | 1851 |
| Аффилиация | Campeotto Florence; Néonatologie et Gastroentérologie pédiatrique, APHP, Groupe Hospitalier Cochin-Saint Vincent de Paul, Université Paris Descartes; Ecosystème intestinal, probiotiques, antibiotiques (EA 4065), Université Paris Descartes |
| Аффилиация | Suau Antonia; EA 3199, Conservatoire National des Arts et Métiers |
| Аффилиация | Kapel Nathalie; Ecosystème intestinal, probiotiques, antibiotiques (EA 4065), Université Paris Descartes; Coprologie fonctionnelle, APHP, Groupe hospitalier Pitié-Salpêtrière, 47–83 boulevard de l'Hôpital |
| Аффилиация | Magne Fabien; EA 3199, Conservatoire National des Arts et Métiers |
| Аффилиация | Viallon Vivian; Biostatistique, APHP, Groupe Hospitalier Cochin-Port Royal |
| Аффилиация | Ferraris Laurent; Ecosystème intestinal, probiotiques, antibiotiques (EA 4065), Université Paris Descartes |
| Аффилиация | Waligora-Dupriet Anne-Judith; Ecosystème intestinal, probiotiques, antibiotiques (EA 4065), Université Paris Descartes |
| Аффилиация | Soulaines Pascale; Néonatologie et Gastroentérologie pédiatrique, APHP, Groupe Hospitalier Cochin-Saint Vincent de Paul, Université Paris Descartes |
| Аффилиация | Leroux Bernard; Néonatologie, Unité Mère-Enfant Alix de Champagne |
| Аффилиация | Kalach Nicolas; Néonatologie et Gastroentérologie pédiatrique, APHP, Groupe Hospitalier Cochin-Saint Vincent de Paul, Université Paris Descartes |
| Аффилиация | Dupont Christophe; Néonatologie et Gastroentérologie pédiatrique, APHP, Groupe Hospitalier Cochin-Saint Vincent de Paul, Université Paris Descartes; Service d'Explorations Fonctionnelles Digestives Pédiatriques, Gastroentérologie et Allergie alimentaire, Hôpital Necker-Enfants Malades, 149 rue de Sèvres |
| Аффилиация | Butel Marie-José; Ecosystème intestinal, probiotiques, antibiotiques (EA 4065), Université Paris Descartes |
| Выпуск | 12 |
