| Автор | Wheeler, Simon J. |
| Автор | Poston, Lucilla |
| Автор | Thomas, Jane E. |
| Автор | Seed, Paul T. |
| Автор | Baker, Philip N. |
| Автор | Sanders, Thomas A. B. |
| Дата выпуска | 2011 |
| dc.description | Adolescents are at a greater risk of adverse pregnancy outcome, including spontaneous preterm delivery and fetal growth restriction, and typically have a poorer-quality diet than adults have. In the present study, we addressed the hypothesis that low maternal dietary intake of n-3 long-chain PUFA (LCP) status adversely influences pregnancy outcome. A total of 500 adolescents (14–18 years) were recruited at ≤ 20 weeks' gestation. The frequency of consumption of oily fish was determined by questionnaire (at recruitment and during the third trimester). The fatty acid composition of plasma lipids during the third trimester was determined in 283 subjects. Principal components analysis (PCA) was used to derive components, which were divided into tertiles. The pregnancy outcomes were then compared by tertile, adjusting for potentially confounding variables. Of the participants, 69 % reported never eating oily fish during pregnancy, although consumption was not associated with a shorter duration of gestation (P = 0·33), lower customised birth weight (P = 0·82) or higher incidence of small-for-gestational age (SGA) birth (P = 0·55). PCA of the fatty acid composition of maternal plasma lipids identified a ‘low PUFA:SFA (P:S) ratio’ component and a ‘high n-3 LCP’ component. There were no differences between tertiles of the ‘high n-3 LCP’ component and gestational age at delivery (P = 0·62), customised birth weight (P = 0·38) or incidence of SGA birth (P = 0·25), nor were there any associations between the ‘low P:S’ ratio component and pregnancy outcome. Lower proportions of n-3 LCP in plasma lipids are not associated with greater risk of adverse pregnancy outcomes in UK adolescents. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2010 |
| Тема | Adolescent pregnancy |
| Тема | n-3 PUFA |
| Тема | Fatty acids |
| Тема | Diet |
| Тема | Human and Clinical Nutrition |
| Название | Maternal plasma fatty acid composition and pregnancy outcome in adolescents |
| Тип | research-article |
| DOI | 10.1017/S0007114510004083 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 105 |
| Первая страница | 601 |
| Последняя страница | 610 |
| Аффилиация | Wheeler Simon J.; King's College London |
| Аффилиация | Poston Lucilla; King's College London |
| Аффилиация | Thomas Jane E.; King's College London |
| Аффилиация | Seed Paul T.; King's College London |
| Аффилиация | Baker Philip N.; School of Laboratory and Clinical Sciences, University of Manchester, St Mary's Hospital |
| Аффилиация | Sanders Thomas A. B.; King's College London |
| Выпуск | 4 |
