| Автор | Berry, Sarah E. |
| Автор | Mulla, Umme Z. |
| Автор | Chowienczyk, Philip J. |
| Автор | Sanders, Thomas A. B. |
| Дата выпуска | 2010 |
| dc.description | K-rich fruit and vegetables may lower blood pressure (BP) and improve vascular function. A randomised controlled trial (ISRCTN50011192) with a cross-over design was conducted in free-living participants with early stages of hypertension (diastolic BP>80 and < 100 mmHg, not receiving BP-lowering medication) to test this hypothesis. Following a 3-week run-in period on a control diet, each subject completed four dietary 6-week dietary interventions (control+placebo capsules, an additional 20 or 40 mmol K<sup>+</sup>/d from fruit and vegetables or 40 mmol potassium citrate capsules/d) using a Latin square design with a washout period ≥ 5 weeks between the treatment periods. Out of fifty-seven subjects who were randomised, twenty-three male and twenty-five female participants completed the study; compliance to the intervention was corroborated by food intake records and increased urinary K<sup>+</sup> excretion; plasma lipids, vitamin C, folate and homocysteine concentrations, urinary Na excretion, and body weight remained were unchanged. On the control diet, mean ambulatory 24 h systolic/diastolic BP were 132·3 (sd 12·0)/81·9 (sd 7·9) mmHg, and changes (Bonferroni's adjusted 95 % CI) compared with the control on the diets providing 20 and 40 mmol K<sup>+</sup>/d as fruit and vegetables were 0·8 ( − 3·5, 5·3)/0·8 ( − 1·9, 3·5) and 1·7 ( − 3·0, 5·3)/1·5 ( − 1·5, 4·4), respectively, and were 1·8 ( − 2·1, 5·8)/1·4 ( − 1·6, 4·4) mmHg on the 40 mmol potassium citrate supplement, and were not statistically significant. Arterial stiffness, endothelial function, and urinary and plasma isoprostane and C-reactive protein (CRP) concentrations did not differ significantly between the diets. The present study provides no evidence to support dietary advice to increase K intake above usual UK intakes in the subjects with early stages of hypertension. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2010 |
| Тема | Blood pressure |
| Тема | Potassium |
| Тема | Fruit and vegetables |
| Тема | Endothelial function |
| Тема | Arterial stiffness |
| Тема | Isoprostanes |
| Тема | Human and Clinical Nutrition |
| Название | Increased potassium intake from fruit and vegetables or supplements does not lower blood pressure or improve vascular function in UK men and women with early hypertension: a randomised controlled trial |
| Тип | research-article |
| DOI | 10.1017/S0007114510002904 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 104 |
| Первая страница | 1839 |
| Последняя страница | 1847 |
| Аффилиация | Berry Sarah E.; Nutritional Sciences Division, King's College London |
| Аффилиация | Mulla Umme Z.; Nutritional Sciences Division, King's College London |
| Аффилиация | Chowienczyk Philip J.; Cardiovascular Science Division, St Thomas' Hospital |
| Аффилиация | Sanders Thomas A. B.; Nutritional Sciences Division, King's College London |
| Выпуск | 12 |
