| Автор | Prosser, Nicolas R. |
| Автор | Heath, Anne-Louise M. |
| Автор | Williams, Sheila M. |
| Автор | Gibson, Rosalind S. |
| Дата выпуска | 2010 |
| dc.description | Interventions to combat mild Fe deficiency in women of childbearing age may affect Zn nutriture. We used dietary and laboratory indices to assess change in Zn status during a 4-month partially blinded placebo-controlled Fe intervention in women with low Fe stores (serum ferritin < 20 μg/l and Hb ≥ 120 g/l) from Dunedin, New Zealand. Subjects aged 18–40 years were randomly assigned to three groups: dietary advice (diet group; DG; n 29), daily Fe supplement with meals (supplement group; SG; n 23; 50 mg Fe as amino acid chelate) and placebo (placebo group; PG, n 26). A validated semi-quantitative FFQ (SFFQ) was administered at baseline, and at 4, 8 and 15 weeks; fasting morning blood samples were assayed for serum Zn, alkaline phosphatase (ALP) and C-reactive protein at baseline, and at 4, 8, 12 and 16 weeks; hair Zn and taste detection thresholds by electrogustometry were measured at baseline and at 16 weeks. Intakes of flesh foods and vitamin C but not Zn or Fe increased, whereas phytate and phytate:Zn molar ratios decreased (all P ≤ 0·01) in the DG compared with the PG and SG, based on three SFFQ. Serum Zn increased in both the DG and PG (adjusted, P ≤ 0·002), so the between-group difference was not significant; the lack of a parallel rise in the SG was significant when compared with the PG (P = 0·02). ALP activity (but not hair Zn or taste acuity) followed a similar trend. In conclusion, Zn status was not improved compared with placebo by an Fe-based dietary intervention. However, a daily moderate-dose Fe supplement with meals appeared to lower Zn status in these young adult women. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2010 |
| Тема | Serum zinc |
| Тема | Iron–zinc interaction |
| Тема | Iron supplements |
| Тема | Dietary interventions |
| Тема | Randomised controlled trials |
| Тема | Human and Clinical Nutrition |
| Название | Influence of an iron intervention on the zinc status of young adult New Zealand women with mild iron deficiency |
| Тип | research-article |
| DOI | 10.1017/S0007114510001091 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 104 |
| Первая страница | 742 |
| Последняя страница | 750 |
| Аффилиация | Prosser Nicolas R.; University of Otago |
| Аффилиация | Heath Anne-Louise M.; University of Otago |
| Аффилиация | Williams Sheila M.; University of Otago |
| Аффилиация | Gibson Rosalind S.; University of Otago |
| Выпуск | 5 |
