| Автор | Azzini, Elena |
| Автор | Vitaglione, Paola |
| Автор | Intorre, Federica |
| Автор | Napolitano, Aurora |
| Автор | Durazzo, Alessandra |
| Автор | Foddai, Maria S. |
| Автор | Fumagalli, Alessandro |
| Автор | Catasta, Giovina |
| Автор | Rossi, Laura |
| Автор | Venneria, Eugenia |
| Автор | Raguzzini, Anna |
| Автор | Palomba, Lara |
| Автор | Fogliano, Vincenzo |
| Автор | Maiani, Giuseppe |
| Дата выпуска | 2010 |
| dc.description | Strawberries contain many antioxidant phytochemicals such as vitamin C, carotenoids and phenolic compounds including anthocyanins (ACN). In the present study, antioxidant composition of fresh strawberries (FS) and stored strawberries (SS) and the bioavailability of the main strawberry bioactive compounds were determined in human subjects. Thirteen healthy volunteers consumed 300 g of FS and SS on two separate occasions. Blood, before and at different time points from meal consumption, as well as 24 h urine, was collected, and parent compounds and metabolites of the different compounds were determined by HPLC or LC/MS/MS. A reduction in α-carotene plasma concentrations v. baseline values was recorded after the consumption of FS, although the amount of this carotenoid was higher in the SS. On the contrary, a significant increase of plasma vitamin C after 2, 3 and 5 h (P < 0·05) of FS and SS consumption was recorded. No quercetin and ACN were found in plasma, while coumaric acid, 4-hydroxybenzoic acid (4HBA, 56 and 54 % of pelargonidin-3-glucoside (Pel-glc) ingested with FS and SS, respectively) and protocatechuic acid (59 and 34 % of cyanidin-3-glucoside ingested with FS and SS, respectively) over 8 h from strawberry consumption were retrieved in the plasma. Pelargonidin glucuronide, pelargonidin glucoside and pelargonidin aglycone peaked in urine within 2 h of strawberry consumption, and the 24 h amount excreted was always approximately 0·9 % of the Pel-glc dose ingested. The data indicated that the content of phytochemicals in strawberries may influence the bioavailability of individual compounds. Furthermore, in the present study, the metabolism of Pel-glc was elucidated, and, for the first time, 4HBA was suggested to be a major human metabolite of Pel-glc. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2010 |
| Тема | Anthocyanins |
| Тема | Bioavailability |
| Тема | Metabolism |
| Тема | Phenolic acids |
| Тема | Strawberries |
| Тема | Human and Clinical Nutrition |
| Название | Bioavailability of strawberry antioxidants in human subjects |
| Тип | research-article |
| DOI | 10.1017/S000711451000187X |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 104 |
| Первая страница | 1165 |
| Последняя страница | 1173 |
| Аффилиация | Azzini Elena; National Institute for Food and Nutrition Research |
| Аффилиация | Vitaglione Paola; University of Naples Federico II |
| Аффилиация | Intorre Federica; National Institute for Food and Nutrition Research |
| Аффилиация | Napolitano Aurora; University of Naples Federico II |
| Аффилиация | Durazzo Alessandra; National Institute for Food and Nutrition Research |
| Аффилиация | Foddai Maria S.; National Institute for Food and Nutrition Research |
| Аффилиация | Fumagalli Alessandro; National Institute for Food and Nutrition Research |
| Аффилиация | Catasta Giovina; National Institute for Food and Nutrition Research |
| Аффилиация | Rossi Laura; National Institute for Food and Nutrition Research |
| Аффилиация | Venneria Eugenia; National Institute for Food and Nutrition Research |
| Аффилиация | Raguzzini Anna; National Institute for Food and Nutrition Research |
| Аффилиация | Palomba Lara; National Institute for Food and Nutrition Research |
| Аффилиация | Fogliano Vincenzo; University of Naples Federico II |
| Аффилиация | Maiani Giuseppe; National Institute for Food and Nutrition Research |
| Выпуск | 8 |
