| Автор | Witthöft, Cornelia M. |
| Автор | Arkbåge, Karin |
| Автор | Johansson, Madelene |
| Автор | Lundin, Eva |
| Автор | Berglund, Gerd |
| Автор | Zhang, Jie-Xian |
| Автор | Lennernäs, Hans |
| Автор | Dainty, Jack R. |
| Дата выпуска | 2006 |
| dc.description | Data on folate absorption from food from validated human studies using physiological folate doses are still needed to estimate dietary requirements and to formulate recommendations. The aim of the present work was to study the effects from fortified and processed foods on folate absorption in ileostomy volunteers (n 9) using the area under the plasma concentration curve (AUC) and kinetic modelling. Using a standardized single-dose protocol, dairy products fortified with a candidate fortificant (6S)-5-methyltetrahydrofolate ((6S)-5-CH<sub>3</sub>-H<sub>4</sub>folate), folic acid-fortified bread and a dessert crème containing natural yeast folate polyglutamates were compared with folate supplements. Absorbed folate was estimated by AUC and a kinetic model, and non-absorbed folate by ileostomal folate excretion. Median apparent absorption from test foods ranged from 55 to 86%. Added folate-binding proteins (FBP) significantly reduced folate absorption from dairy products, as in the absence of FBP, AUC–dose-corrected ratios were increased and ileal folate excretion decreased. After in vivo gastrointestinal passage of dairy products containing FBP, up to 43% of the ingested FBP was found in ileostomal effluent. Folate absorption was similar for (6S)-5-CH<sub>3</sub>-H<sub>4</sub>folate fortificant from fermented milk and for folic acid from fortified bread. Folic acid, ingested as food fortificant in bread, was significantly less absorbed compared with an isolated supplement. We conclude that all tested foods were suitable matrices for folate fortification. However, dairy products, fortified with the new candidate fortificant (6S)-5-CH<sub>3</sub>-H<sub>4</sub>folate, are suitable if no active FBP is present. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Nutrition Society 2006 |
| Тема | (6S)-5-Methyltetrahydrofolate/folic acid |
| Тема | Folate-binding proteins |
| Тема | Fortified foods |
| Тема | Human folate absorption |
| Название | Folate absorption from folate-fortified and processed foods using a human ileostomy model |
| Тип | research-article |
| DOI | 10.1079/BJN20051620 |
| Electronic ISSN | 1475-2662 |
| Print ISSN | 0007-1145 |
| Журнал | British Journal of Nutrition |
| Том | 95 |
| Первая страница | 181 |
| Последняя страница | 187 |
| Аффилиация | Witthöft Cornelia M.; Swedish University of Agricultural Sciences |
| Аффилиация | Arkbåge Karin; Swedish University of Agricultural Sciences |
| Аффилиация | Johansson Madelene; Swedish University of Agricultural Sciences |
| Аффилиация | Lundin Eva; University of Umeå |
| Аффилиация | Berglund Gerd; University of Umeå |
| Аффилиация | Zhang Jie-Xian; University of Umeå |
| Аффилиация | Lennernäs Hans; University of Uppsala |
| Аффилиация | Dainty Jack R.; Institute of Food Research |
| Выпуск | 1 |
