| Автор | Munoz, M.J. |
| Автор | Llovería, P. |
| Автор | Santos, M.P. |
| Автор | Abadía, A.R. |
| Автор | Aramayona, J.J. |
| Автор | Bregante, M.A. |
| Дата выпуска | 1996 |
| dc.description | SummaryThe disposition and urinary excretion of ciprofloxacin (CIP) following intravenous (IV) or intramuscular (IM) administration of 7.5 mg/kg body weight in sheep (n = 5) was studied. The intravenous plasma concentration curve was best described pharmacokinetically by a two‐compartment open model, while the intramuscular administration data fitted better to a one‐compartment open model. Mean elimination half‐lives after IV and IM administration were 72 and 184 minutes, respectively. The absorption of intramuscularly administered CIP in sheep was fast: maximal plasma concentration (Cmax) was reached quickly (tmax 31.93 min) and attained values of 0.69 ± 0.27 mg/l. The bioavailability was 49%. The urinary data showed a significant decrease in the elimination rate constant of CIP when CIP was administered intramuscularly. The other parameters calculated did not display differences between the two routes of administration. The results obtained suggest that when CIP was administered by the IM route in the assayed dose, it was able to maintain serum concentrations above the MIC of most common pathogens over an 8‐hour period. |
| Формат | application.pdf |
| Издатель | Taylor & Francis Group |
| Копирайт | Copyright Taylor and Francis Group, LLC |
| Название | Pharmacokinetics of ciprofloxacin in sheep after single intravenous or intramuscular administration |
| Тип | research-article |
| DOI | 10.1080/01652176.1996.9694613 |
| Electronic ISSN | 1875-5941 |
| Print ISSN | 0165-2176 |
| Журнал | Veterinary Quarterly |
| Том | 18 |
| Первая страница | 45 |
| Последняя страница | 48 |
| Аффилиация | Munoz, M.J.; Department of Pharmacology, Veterinary School, University of Zaragoza |
| Аффилиация | Llovería, P.; Department of Pharmacology, Veterinary School, University of Zaragoza |
| Аффилиация | Santos, M.P.; Department of Pharmacology, Veterinary School, University of Zaragoza |
| Аффилиация | Abadía, A.R.; Department of Pharmacology, Veterinary School, University of Zaragoza |
| Аффилиация | Aramayona, J.J.; Department of Pharmacology, Veterinary School, University of Zaragoza |
| Аффилиация | Bregante, M.A.; Department of Pharmacology, Veterinary School, University of Zaragoza |
| Выпуск | 2 |
| Библиографическая ссылка | Abadia, AR, Aramayona, JJ, Munoz, MJ, Pla‐Delfina, JM, Saez, MP and Bregante, MA. 1994. Disposition of ciprofloxacin following intravenous administration in dogs. J Vet Pharmacol Therap, 17: 384–8. |
| Библиографическая ссылка | Abadía, AR, Aramayona, JJ, Fraile, L, Martinez, C, Garcia, MA and Bregante, MA. 1994. Pharmacokinetics of enrofloxacin and ciprofloxacin during ontogeny in the rabbit. Proc. 6th EAVPT Congress. 1994. Edited by: Lees, P, Baggot, DChantler, P. pp.231Word, Blackwell Sci. Publ.. |
| Библиографическая ссылка | Barriere, SL, Kaatz, GW and Schaberg, DR. 1987. Altered pharmacokinetic disposition of ciprofloxacin and vancomycin after single and multiple doses in rabbits. Antimicrob Agents Chemother, 31: 1075–8. |
| Библиографическая ссылка | Budsberg, SC, Douglas, TK and Wolshi, N. 1992. Pharmacokinetics of clindamycin phosphate in dogs after single intravenous and intramuscular administrations. Am J Vet Res, 53: 2333–6. |
| Библиографическая ссылка | Campoli‐Richards, DM, Monk, JPPrice, A. 1988. Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs, 35: 373–447. |
| Библиографическая ссылка | Drusano, GL, Weir, M, Forrest, A, Plaisance, K, Emm, T and Standiford, C. 1987. Pharmacokinetics of intravenously administered ciprofloxacin in patients with various degrees of renal function. Antimicrob Agents Chemother, 31: 860–4. |
| Библиографическая ссылка | Gibaldi, M and Perrier, D. 1982. Pharmacokinetics, New York: Marcel Dekker. |
| Библиографическая ссылка | Gonzalez, MA, Moranchel, AHDuran, S. 1985. Multiple‐dose pharmacokinetics of ciprofloxacin administered intravenously to normal volunteers. Antimicrob Agents Chemother, 28: 235–9. |
| Библиографическая ссылка | Hoffken, G, Lode, H, Parinzing, C, Borner, K and Koeppe, P. 1985. Pharmacokinetics of ciprofloxacin after oral and parenteral administration. Antimicrob Agents Chemother, 27: 375–9. |
| Библиографическая ссылка | Lebel, M, Vallee, F and Bergeron, MG. 1986. Tissue penetration of ciprofloxacin after single and multiple doses. Antimicrob Agents Chemother, 29: 501–5. |
| Библиографическая ссылка | Metzler, CG. 1986. PCNONLIN. Software for the statistical analysis of nonlinear models. Am Statist, 40: 52 |
| Библиографическая ссылка | Neu, HC. 1987. Ciprofloxacin: a major advance in quionolone chemotherapy. Am J Med, 82(suppl. 4A): 1 |
| Библиографическая ссылка | Nouws, JFM, Grondel, JLSchutte, AR. 1988. Pharmacokinetics of ciprofloxacin in carp, african catfish and rainbow trout. Vet Quart, 10: 211–6. |
| Библиографическая ссылка | Nouws, JFM, Mevius, DJVree, TV. 1988. Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Vet Quart, 10: 156–63. |
| Библиографическая ссылка | Park, SC, Yun, HI, Choi, YY and Oh, TK. 1994. Pharmacokinetics of norfloxacin in horses and rabbits after intravenous, intramuscular or oral administration. Proc. 6<sup>th</sup> EAVPT Congress. 1994. Edited by: Lees, P, Baggot, DChantler, P. pp.46–7. Oxford: Blackwell Sci. Publi.. |
| Библиографическая ссылка | Plaisance, KI, Drusano, GL, Forrest, A, Bustamante, CK and Standiford, HC. 1987. Effect of dose size on bioavailability of ciprofloxacin. Antimicrob Agents Chemother, 31: 956–8. |
| Библиографическая ссылка | Pyörälä, S, Panu, S and Kaartinen, L. 1994. Single‐dose pharmacokinetics of enrofloxacin in horses. Proc. 6<sup>th</sup> EAVPT Congress. 1994. Edited by: Lees, P, Baggot, DChantler, P. pp.45–6. Oxford: Blackwell Sci. Publ.. |
| Библиографическая ссылка | Riviere, JE. 1988. Veterinary clinical pharmacokinetics. Part II. Modeling. Compend Contin Educ Pract Vet, 10: 314–28. |
| Библиографическая ссылка | Schentag, JJ. 1985. Clinical significance of antibiotic tissue penetration. Clin Pharmacokin, 16(1): 25–31. |
| Библиографическая ссылка | Siefert, HM, Maruhn, DMaul, W. 1986. Pharmacokinetics of ciprofloxacin. 1st communication: absorption, concentrations in plasma, metabolism and excretion after single administration of 14C‐ciprofloxacin in albino rats and rhesus monkeys. Arzneim‐Forsch, 36: 1496–1502. |
| Библиографическая ссылка | Siefert, HM, Maruhn, DScholl, H. 1986. Pharmacokinetics of ciprofloxacin. 2<sup>nd</sup> communication: Distribution to and elimination from tissues and organs following single or repeated administration of 14C‐ciprofloxacin in albino rats. Arzneim‐Forsch, 36: 1503–10. |
| Библиографическая ссылка | Tyczkowska, K, Hedeen, KV, Aucoin, DP and Aronson, AL. 1989. High‐performance liquid chromatographic method for the simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in canine serum and prostatic tissue. J Chromatogr, 493: 337–46. |
| Библиографическая ссылка | Vance‐Bryan, K, Guay, DRP and Rotschafer, JC. 1990. Clinical pharmacokinetics of ciprofloxacin. Clin Pharmacokin, 19: 434–61. |
| Библиографическая ссылка | Vancutsem, PM, Babish, JG and Schwark, WS. 1990. The fluorquinolone antimicrobials: structure, antimicrobial activity, pharmacokinetics, clinical use in domestic animals and toxicity. Cornell Vet, 80: 173–86. |
| Библиографическая ссылка | Wagner, JG. 1983. Farmacocinética clinica, Barcelona: Reverté. |
| Библиографическая ссылка | Walker, RD, Stein, GEHauptman, JG. 1990. Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs. Am J Vet Res, 51: 896–900. |
| Библиографическая ссылка | Wise, R, Lockley, RWebberly, M. 1984. Pharmacokinetics of intravenously administered ciprofloxacin. Antimicrob Agents Chemother, 26: 208–10. |
| Библиографическая ссылка | Yun, HI, Park, SC, Jun, MH, Hur, W and Oh, TK. 1994. Ciprofloxacin in horses: antimicrobial activity, protein binding, and pharmacokinetics. Proc. 6th EAVPT Congress. 1994. Edited by: Lees, P, Baggot, DChantler, P. pp.28–9. Oxford: Blackwell Sci. Publ.. |
