| Автор | Davis H. Daiker, Mary Treinen Moslen, James B. Carr, Jonathan B. Ward |
| Дата выпуска | 1996 |
| dc.description | Benzene is a known carcinogen and hematopoietic toxin in humans and experimental animals. The effect of acute, high-dose exposure to benzene on hepatic bioactivation and detoxication enzymes has been defined, while little is known about the effect of repeated, low-dose benzene exposure on these enzymes. Our objective was to determine whether repeated, oral benzene exposure alters enzymes involved in benzene metabolism. Specifically, we were concerned with cytochrome P-450-2E1, a bioactivation enzyme, and glutathione transferase and aldehyde dehydrogenase, two detoxifying enzymes. Female CD-1 mice were treated by gavage for 3 wk with benzene doses of 5 mg/kg (0.064 mmol/kg) or 50 mg/kg (0.646 mmol/kg) in corn oil. These doses of benzene produced 0.048 and 0.236 mumol muconic acid/d, respectively. We found that repeated exposure to 50 mg benzene/kg/d decreased P-450-2E1 activity by 34% and induced glutathione transferase activity by 30% without affecting aldehyde dehydrogenase activity. These changes in enzyme activities may serve a protective role against repeated exposure to benzene. |
| Формат | application.pdf |
| Издатель | Informa UK Ltd |
| Копирайт | Copyright Taylor and Francis Group, LLC |
| Название | REPEATED ORAL BENZENE EXPOSURE ALTERS ENZYMES INVOLVED IN BENZENE METABOLISM |
| Тип | research-article |
| DOI | 10.1080/009841096161177 |
| Print ISSN | 0098-4108 |
| Журнал | Journal of Toxicology and Environmental Health |
| Том | 48 |
| Первая страница | 439 |
| Последняя страница | 440 |
| Выпуск | 5 |
