| Автор | CYSIQUE, LUCETTE A. |
| Автор | JIN, HUA |
| Автор | FRANKLIN, DONALD R. |
| Автор | MORGAN, ERIN E. |
| Автор | SHI, CHUAN |
| Автор | YU, XIN |
| Автор | WU, ZUNYOU |
| Автор | TAYLOR, MICHAEL J. |
| Автор | MARCOTTE, THOMAS D. |
| Автор | LETENDRE, SCOTT |
| Автор | AKE, CHRISTOPHER |
| Автор | GRANT, IGOR |
| Автор | HEATON, ROBERT K. |
| Автор | GROUP, THE HNRC |
| Дата выпуска | 2007 |
| dc.description | The HIV epidemic in China has been increasing exponentially, yet there have been no studies of the neurobehavioral effects of HIV infection in that country. Most neuroAIDS research has been conducted in Western countries using Western neuropsychological (NP) methods, and it is unclear whether these testing methods are appropriate for use in China. Twenty-eight HIV seropositive (HIV+) and twenty-three HIV seronegative (HIV−) individuals with comparable gender, age, and education distributions were recruited in Beijing and the rural Anhui province in China. Thirty-nine HIV+ and thirty-one HIV− individuals were selected from a larger U.S. cohort recruited at the HIV Neurobehavioral Research Center, in San Diego, to be matched to the Chinese sample for age, disease status, and treatment variables. The NP test battery used with the U.S. and China cohorts included instruments widely used to study HIV infection in the United States. It consisted of 14 individual test measures, each assigned to one of seven ability areas thought to be especially vulnerable to effects of HIV on the brain (i.e., verbal fluency, abstraction/executive function, speed of information processing, working memory, learning, delayed recall, and motor function). To explore the cross-cultural equivalence and validity of the NP measures, we compared our Chinese and U.S. samples on the individual tests, as well as mean scaled scores for the total battery and seven ability domains. On each NP test measure, the mean of the Chinese HIV+ group was worse than that of the HIV− group. A series of 2 × 2 analyses of variance involving HIV+ and HIV− groups from both countries revealed highly significant HIV effects on the Global and all Domain mean scaled scores. Country effects appeared on two of the individual ability areas, at least partly due to education differences between the two countries. Importantly, the absence of HIV-by-Country interactions suggests that the NP effects of HIV are similar in the two countries. The NP test battery that was chosen and adapted for use in this study of HIV in China appears to have good cross-cultural equivalence, but appropriate Chinese norms will be needed to identify disease-related impairment in individual Chinese people. To inform the development of such norms, a much larger study of demographic effects will be needed, especially considering the wide range of education in that country. (JINS, 2007, 13, 781–790.) |
| Издатель | Cambridge University Press |
| Тема | HIV/AIDS |
| Тема | Neuropsychological functioning |
| Тема | Cognition |
| Тема | China |
| Тема | Cross-cultural assessment |
| Тема | Everyday functioning |
| Название | Neurobehavioral effects of HIV-1 infection in China and the United States: A pilot study |
| DOI | 10.1017/S1355617707071007 |
| Electronic ISSN | 1469-7661 |
| Print ISSN | 1355-6177 |
| Журнал | Journal of the International Neuropsychological Society |
| Том | 13 |
| Первая страница | 781 |
| Последняя страница | 790 |
| Аффилиация | CYSIQUE LUCETTE A.; University of California at San Diego |
| Аффилиация | JIN HUA; University of California at San Diego; VA San Diego Health Care System |
| Аффилиация | FRANKLIN DONALD R.; University of California at San Diego |
| Аффилиация | MORGAN ERIN E.; University of California at San Diego |
| Аффилиация | SHI CHUAN; Peking University |
| Аффилиация | YU XIN; Peking University |
| Аффилиация | WU ZUNYOU; Peking University |
| Аффилиация | TAYLOR MICHAEL J.; University of California at San Diego |
| Аффилиация | MARCOTTE THOMAS D.; University of California at San Diego |
| Аффилиация | LETENDRE SCOTT; University of California at San Diego |
| Аффилиация | AKE CHRISTOPHER; University of California at San Diego |
| Аффилиация | GRANT IGOR; University of California at San Diego |
| Аффилиация | HEATON ROBERT K.; University of California at San Diego; VA San Diego Health Care System; University of California, San Diego |
| Аффилиация | GROUP THE HNRC; University of California at San Diego |
| Выпуск | 5 |
