| Автор | MUSLIMOVIĆ, DINO |
| Автор | SCHMAND, BEN |
| Автор | SPEELMAN, JOHANNES D. |
| Автор | DE HAAN, ROB J. |
| Дата выпуска | 2007 |
| dc.description | A meta-analysis was conducted on 25 longitudinal studies involving 901 initially non-demented Parkinsonʼs disease (PD) patients to examine the magnitude of decline across multiple cognitive domains associated with disease progression. Pooled effect sizes reflecting the standardized difference between baseline and follow-up neuropsychological performance were calculated for 8 cognitive domains using a random-effects model. Relatively small effect sizes were found across all cognitive domains (d = .00 − .40). During a mean follow-up interval of 29 months, significant declines were detected in global cognitive ability (d = .40), visuoconstructive skills (d = .32), and memory (d = .29). Age showed a significant relation with decline in global cognitive ability and memory. Lower educational level was associated with greater decline in all cognitive domains. Studies with longer follow-up intervals yielded larger effect sizes for global cognitive ability. In non-demented PD patients, changes in cognitive functions over time appear to be modest. Educational level, age, and length of the follow-up interval are likely to affect the magnitude of decline in several domains. Methodological flaws, such as selection bias and uncontrolled practice effects, may have caused underestimation of the true extent of decline (JINS, 2007, 13, 920–932.) |
| Издатель | Cambridge University Press |
| Тема | Parkinsonʼs disease |
| Тема | Cognitive decline |
| Тема | Neuropsychological tests |
| Тема | Longitudinal studies |
| Тема | Prognosis |
| Тема | Meta-analysis |
| Название | Course of cognitive decline in Parkinsonʼs disease: A meta-analysis |
| DOI | 10.1017/S1355617707071160 |
| Electronic ISSN | 1469-7661 |
| Print ISSN | 1355-6177 |
| Журнал | Journal of the International Neuropsychological Society |
| Том | 13 |
| Первая страница | 920 |
| Последняя страница | 932 |
| Аффилиация | MUSLIMOVIĆ DINO; University of Amsterdam; AMC Neurology |
| Аффилиация | SCHMAND BEN; University of Amsterdam; University of Amsterdam |
| Аффилиация | SPEELMAN JOHANNES D.; University of Amsterdam |
| Аффилиация | DE HAAN ROB J.; University of Amsterdam |
| Выпуск | 6 |
