The purpose of this study was to determine the patterns and best predictors of experimentation and use of drugs by a suburban upper middle class adolescent (5th grade though high school) population. The data show increasing percentages of students involved with drugs across the grades, differences in involvement for females compared to males, distinctions between the most popular drugs (alcohol, marijuana and cigarettes) and other less popular drugs and factors associated with trial and use of the various drugs. Some statements are made in conclusion about the meaning and use of this data for drug education and prevention.