Synthesis of Substituted-Benzyl and Sugar-Modified Analogues of 6-N-(4-Nitrobenzyl)adenosine and Their Interactions with “ES” Nucleoside Transport Systems
Robins, Morris J.; Asakura, Jun-ichi; Kaneko, Masakatsu; Shibuya, Susumu; Jakobs, Ewa S.; Agbanyo, Francisca R.; Cass, Carol E.; Paterson, Alan R. P.; Robins, Morris J.; Department of Chemistry, University of Alberta; Department of Chemistry, Brigham Young University; Asakura, Jun-ichi; Department of Chemistry, University of Alberta; Department of Chemistry, Brigham Young University; Kaneko, Masakatsu; Department of Chemistry, University of Alberta; Shibuya, Susumu; Department of Chemistry, University of Alberta; Jakobs, Ewa S.; Department of McEachern Laboratory, University of Alberta; Agbanyo, Francisca R.; Department of McEachern Laboratory, University of Alberta; Cass, Carol E.; Department of Biochemistry, University of Alberta; Department of McEachern Laboratory, University of Alberta; Paterson, Alan R. P.; Department of Pharmacology, University of Alberta; Department of McEachern Laboratory, University of Alberta
Журнал:
Nucleosides and Nucleotides
Дата:
1994
Аннотация:
AbstractFour classes of 6-X-benzylated purine nucleosides, (i) 6-N-(substituted-benzyl)adenosines, (ii) 6-N-(4-nitrobenzyl)adenine nucleosides with modified sugars, (iii) 6-N(S)-(4-azidobenzyl) derivatives of adenosine, 6-thioinosine, and 6-thioguanosine, and (iv) 6-N-{4-N-[acyl(sulfonyl)amino]benzyl}adenosines, were synthesized and their binding interactions with “es-NT” (equilibrative, inhibitor-sensitive nucleoside transport) systems were studied. Several tight-binding analogues were found.
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