| Автор | DUSSABLY, LAURE M |
| Автор | SOMERSET, DAVID A |
| Автор | KILBY, MARK D |
| Автор | SANSOM, DAVID M |
| Дата выпуска | 2004 |
| dc.description | Since the discovery that major histocompatibility complex (MHC) proteins provide a barrier to tissue transplantation between individuals it has been a paradox that, during pregnancy, the mother is able to retain a fetus that expresses MHC antigens from the father without rejection. The nature of this materno-fetal tolerance is not well understood and may involve multiple mechanisms. However since a major mechanism of histo-incompatible tissue rejection involves T lymphocytes, it seems plausible that controlling T cell responses is likely to be important. Recently, there has been considerable research activity focusing on the role of a sub-set of CD4<sup>+</sup> T cells that express the interleukin-2 receptor chain CD25<sup>+</sup>. These CD4<sup>+</sup>CD25<sup>+</sup> cells are termed regulatory T cells (Treg) based on their ability to prevent autoimmune tissue damage. In this review we discuss recent evidence that may link Treg to materno-fetal tolerance during pregnancy. |
| Издатель | Cambridge University Press |
| Название | A ROLE FOR REGULATORY T CELLS IN MATERNO-FETAL TOLERANCE? |
| DOI | 10.1017/S0965539504001378 |
| Electronic ISSN | 1469-5065 |
| Print ISSN | 0965-5395 |
| Журнал | Fetal and Maternal Medicine Review |
| Том | 15 |
| Первая страница | 299 |
| Последняя страница | 306 |
| Аффилиация | DUSSABLY LAURE M; University of Birmingham |
| Аффилиация | SOMERSET DAVID A; University of Birmingham |
| Аффилиация | KILBY MARK D; University of Birmingham |
| Аффилиация | SANSOM DAVID M; University of Birmingham |
| Выпуск | 4 |
