| Автор | BISHRY, GASSER EL |
| Автор | STURGISS, STEPHEN N |
| Дата выпуска | 2003 |
| dc.description | Fetal growth restriction (FGR) as a consequence of uteroplacental insufficiency is an important contributor to perinatal death, neonatal morbidity and long-term health problems. Progressive uteroplacental dysfunction leads to placental respiratory failure and fetal hypoxaemia, which triggers compensatory fetal haemodynamic changes including blood flow redistribution towards essential fetal organs (brain, heart and adrenal glands) at the expense of the other body systems. The duration of the compensatory phase is variable, sometimes lasting weeks, and appears not to have deleterious short-term consequences. With further disease progression, the compensatory mechanisms reach their limit and myocardial dysfunction occurs. Once the disease enters this decompensatory phase, the fetus is at high risk of multisystem organ failure and in-utero demise. There is no effective in-utero therapeutic intervention. The main aim of management is to deliver the baby when the risks of antenatal demise and irreversible end-organ dysfunction associated with further prolongation of the pregnancy are greater than the risks from delivery. |
| Издатель | Cambridge University Press |
| Название | ABSENT-END-DIASTOLIC FLOW VELOCITY IN THE UMBILICAL ARTERY |
| DOI | 10.1017/S0965539503001116 |
| Electronic ISSN | 1469-5065 |
| Print ISSN | 0965-5395 |
| Журнал | Fetal and Maternal Medicine Review |
| Том | 14 |
| Первая страница | 251 |
| Последняя страница | 271 |
| Аффилиация | BISHRY GASSER EL; James Cook University Hospital |
| Аффилиация | STURGISS STEPHEN N; Royal Victoria Infirmary; Royal Victoria Infirmary |
| Выпуск | 3 |
