Dietary Factors and Risk of Breast Cancer: Combined Analysis of 12 Case—Control Studies
Howe, Geoffrey R.; Hirohata, Tomio; Hislop, T. Gregory; Iscovich, Jose Mario; Yuan, Jian-Min; Katsouyanni, Klea; Lubin, Flora; Marubini, Ettore; Modan, Baruch; Rohan, Thomas; Toniolo, Paolo; Shunzhang, Yu; Howe Geoffrey R.; Epidemiology Unit, National Cancer Institute of Canada, Faculty of Medicine, University of Toronto; Hirohata Tomio; Cancer Research Center of Hawaii, University of Hawaii at Manoa; Hislop T. Gregory; Cancer Control Agency of British Columbia; Iscovich Jose Mario; Department of Epidemiology Studies, Ministry of Health, La Plata, Argentina, and Israel Center for Registration of Cancer and Allied Diseases,; Yuan Jian-Min; Shanghai Cancer Institute, Shanghai, People's Republic of China; Katsouyanni Klea; Department of Hygiene and Epidemiology, University of Athens; Lubin Flora; Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel Aviv University; Marubini Ettore; Istituto di Statistica Medica e Biometria, University of Milan, Istituto Nazionale dei Tumori of Milan; Modan Baruch; Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel Aviv University; Rohan Thomas; Commonwealth Scientific and Industrial Research Organization; Toniolo Paolo; Department of Environmental Medicine, New York University Medical Center; Shunzhang Yu; Shanghai Medical University, Shanghai, People's Republic of China
Журнал:
JNCI: Journal of the National Cancer Institute
Дата:
1990
Аннотация:
We conducted a combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer. Our analysis shows a consistent, statistically significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women (relative risk for highest vs. lowest quintile, 1.46; P <.0001). A consistent protective effect for a number of markers of fruit and vegetable intake was demonstrated; vitamin C intake had the most consistent and statistically significant inverse association with breast cancer risk (relative risk for highest vs. lowest quintile, 0.69; P <.0001). If these dietary associations represent causality, the attributable risk (i.e., the percentage of breast cancers that might be prevented by dietary modification) in the North American population is estimated to be 24% for postmenopausal women and 16% for premeno-pausal women. [J Natl Cancer Inst 82: 561–569, 1990]
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