| Автор | Brachet, Patrick |
| Автор | Chanson, Aurélie |
| Автор | Demigné, Christian |
| Автор | Batifoulier, Frédérique |
| Автор | Alexandre-Gouabau, Marie-Cécile |
| Автор | Tyssandier, Viviane |
| Автор | Rock, Edmond |
| Дата выпуска | 2004 |
| dc.description | The number of elderly individuals is growing rapidly worldwide and degenerative diseases constitute an increasing problem in terms of both public health and cost. Nutrition plays a role in the ageing process and there has been intensive research during the last decade on B vitamin-related risk factors in vascular and neurological diseases and cancers. Data from epidemiological studies indicate that subclinical deficiency in most water-soluble B vitamins may occur gradually during ageing, possibly due to environmental, metabolic, genetic, nutritional and pathological determinants, as well as to lifestyle, gender and drug consumption. Older adults have distinct absorption, cell transport and metabolism characteristics that may alter B vitamin bioavailability. Case–control and longitudinal studies have shown that, concurrent with an insufficient status of certain B vitamins, hyperhomocysteinaemia and impaired methylation reactions may be some of the mechanisms involved before a degenerative pathology becomes evident. The question that arises is whether B vitamin inadequacies contribute to the development of degenerative diseases or result from ageing and disease. The present paper aims to give an overview of these issues at the epidemiological, clinical and molecular levels and to discuss possible strategies to prevent B vitamin deficiency during ageing. |
| Формат | application.pdf |
| Издатель | Cambridge University Press |
| Копирайт | Copyright © The Authors 2004 |
| Тема | Ageing |
| Тема | Micronutrients |
| Тема | B vitamin deficiency |
| Тема | Degenerative diseases |
| Название | Age-associated B vitamin deficiency as a determinant of chronic diseases |
| Тип | research-article |
| DOI | 10.1079/NRR200478 |
| Electronic ISSN | 1475-2700 |
| Print ISSN | 0954-4224 |
| Журнал | Nutrition Research Reviews |
| Том | 17 |
| Первая страница | 55 |
| Последняя страница | 68 |
| Аффилиация | Brachet Patrick; Institut National de la Recherche Agronomique |
| Аффилиация | Chanson Aurélie; Institut National de la Recherche Agronomique |
| Аффилиация | Demigné Christian; Institut National de la Recherche Agronomique |
| Аффилиация | Batifoulier Frédérique; Institut National de la Recherche Agronomique |
| Аффилиация | Alexandre-Gouabau Marie-Cécile; Institut National de la Recherche Agronomique |
| Аффилиация | Tyssandier Viviane; Institut National de la Recherche Agronomique |
| Аффилиация | Rock Edmond; Institut National de la Recherche Agronomique |
| Выпуск | 1 |
